Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.
Lab Chip. 2013 Aug 21;13(16):3253-60. doi: 10.1039/c3lc50472g. Epub 2013 Jun 21.
Expanding upon recent applications of interfacing electricity with centrifugal microfluidic platforms, we introduce electrochemical velocimetry to monitor flow in real-time on rotating fluidic devices. Monitoring flow by electrochemical techniques requires a simple, compact setup of miniaturized electrodes that are embedded within a microfluidic channel and are connected to a peripherally-located potentiostat. On-disc flow rates, determined by electrochemical velocimetry, agreed well with theoretically expected values and with optical measurements. As an application of the presented techniques, the dynamic process of droplet formation and release was recorded, yielding critical information about droplet frequency and volume. Overall, the techniques presented in this work advance the field of centrifugal microfluidics by offering a powerful tool, previously unavailable, to monitor flow in real-time on rotating microfluidic systems.
在最近将电能与离心微流控平台结合的应用基础上，我们引入电化学速度测量法来实时监测旋转流控装置中的流动。通过电化学技术监测流动需要一个简单、紧凑的小型化电极设置，这些电极嵌入微流道中，并与位于外围的电化学工作站相连。通过电化学速度测量法确定的转盘上的流速与理论预期值和光学测量值吻合良好。作为所提出技术的应用，记录了液滴形成和释放的动态过程，提供了关于液滴频率和体积的关键信息。总的来说，本工作中提出的技术通过提供以前无法获得的实时监测旋转微流控系统中流动的强大工具，推动了离心微流控领域的发展。
