Dong Shuangqian, Zhang Jianwei, Zhai Fengting, Zhao Xinglong, Qin Xiuyun
The First Clinical College.
Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan.
Medicine (Baltimore). 2019 Jul;98(29):e16473. doi: 10.1097/MD.0000000000016473.
Endometriosis is a common disease of women of childbearing age. In recent years, the incidence of endometriosis has been on the rise. The main clinical manifestations are pelvic pain and infertility. In recent years, traditional Chinese patent medicine (TCMP) has played an important role in the treatment of endometriosis. So far, there is a lack of comparison among all the current common TCPMs for endometriosis. Consequently, it is indispensable to propose a network meta-analysis (NMA) protocol to discuss the strengths and weaknesses of different TCMPs.
We will comprehensively and systematically retrieve the relevant Chinese and English databases from their inceptions to the May 2019. All randomized controlled trials (RCTs) of TCMPs for Endometriosis will be included. Two researchers will independently screen literature, extract data and assess the risk of bias of included studies. We will conduct pairwise meta-analyses and Bayesian network meta-analyses to assess all the available evidence. Data will be analyzed using STATA and WinBUGS software.
This work will compare and rank the relative efficacy of different TCPMs in the treatment of endometriosis in detail.
The results of this study will provide reliable evidence for the selection of clinical treatment program and guideline development.
CRD42019127781.
子宫内膜异位症是育龄期女性的常见疾病。近年来，子宫内膜异位症的发病率呈上升趋势。主要临床表现为盆腔疼痛和不孕。近年来，中成药在子宫内膜异位症的治疗中发挥了重要作用。目前，对于所有治疗子宫内膜异位症的常用中成药，尚缺乏比较。因此，提出一项网络荟萃分析（NMA）方案以探讨不同中成药的优缺点是必不可少的。
我们将全面、系统地检索从建库至2019年5月的中英文相关数据库。纳入所有关于中成药治疗子宫内膜异位症的随机对照试验（RCT）。两名研究人员将独立筛选文献、提取数据并评估纳入研究的偏倚风险。我们将进行成对荟萃分析和贝叶斯网络荟萃分析以评估所有可用证据。数据将使用STATA和WinBUGS软件进行分析。
本研究将详细比较并排序不同中成药治疗子宫内膜异位症的相对疗效。
本研究结果将为临床治疗方案的选择和指南制定提供可靠依据。
CRD42019127781。
