Neuro-Electronics Research Flanders (NERF), 3001 Leuven, Belgium; Vlaams Institute for Biotechnology (VIB), 3001 Leuven, Belgium; Department of Neuroscience and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium.
Neurosci Res. 2020 May;154:1-8. doi: 10.1016/j.neures.2019.07.005. Epub 2019 Jul 20.
Proprioceptive feedback provides movement-matched sensory information essential for motor control and recovery after spinal cord injury. While it is understood that the fundamental contribution of proprioceptive feedback circuits in locomotor recovery is to activate the local spinal cord interneurons and motor neurons in a context-dependent manner, the precise mechanisms by which proprioception enables motor recovery after a spinal cord injury remain elusive. Furthermore, how proprioception contributes to motor learning mechanisms intrinsic to spinal cord networks and gives rise to motor recovery is currently unknown. This review discusses the existence of motor learning mechanisms intrinsic to spinal cord circuits and circuit-level insights on how proprioception might contribute to spinal cord plasticity, adaptability, and learning, in addition to the logic in which proprioception helps to establish an internal motor command to execute motor output using spared circuits after a spinal cord injury.
本体感觉反馈提供运动匹配的感觉信息，对于脊髓损伤后的运动控制和恢复至关重要。虽然人们已经了解到，本体感觉反馈回路在运动恢复中的基本贡献是以上下文依赖的方式激活局部脊髓中间神经元和运动神经元，但本体感觉如何促进脊髓损伤后的运动恢复的精确机制仍不清楚。此外，本体感觉如何有助于脊髓网络内在的运动学习机制，并导致运动恢复，目前尚不清楚。这篇综述讨论了脊髓回路内在的运动学习机制的存在，以及本体感觉如何有助于脊髓可塑性、适应性和学习的回路水平见解，此外还讨论了本体感觉如何帮助在脊髓损伤后利用保留的回路建立内部运动指令以执行运动输出的逻辑。
