Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA.
Curr Opin Neurobiol. 2018 Dec;53:156-161. doi: 10.1016/j.conb.2018.08.008. Epub 2018 Sep 8.
Proprioceptive sensory input and descending supraspinal projections are two major inputs that feed into and influence spinal circuitry and locomotor behaviors. Here we review their influence on each other during development and after spinal cord injury. We highlight developmental mechanisms of circuit formation as they relate to the sensory-motor circuit and its reciprocal interactions with local spinal interneurons, as well as competitive interactions between proprioceptive and descending supraspinal inputs in the setting of spinal cord injury.
本体感觉传入和下行脊髓上投射是输入和影响脊髓回路和运动行为的两个主要输入。在这里,我们回顾了它们在发育过程中和脊髓损伤后彼此的影响。我们强调了与感觉运动回路相关的回路形成的发育机制,以及它与其局部脊髓中间神经元的相互作用,以及在脊髓损伤的情况下本体感觉传入和下行脊髓上传入之间的竞争相互作用。