Cui Zhengzhe, Li Yongqiang, Huang Sisi, Wu Xixi, Fu Xiangxiang, Liu Fei, Wan Xiaojiao, Wang Xue, Zhang Yuting, Qiu Huaide, Chen Fang, Yang Peijin, Zhu Shiqiang, Li Jianan, Chen Weidong
School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cogn Neurodyn. 2022 Dec;16(6):1283-1301. doi: 10.1007/s11571-022-09801-6. Epub 2022 Apr 10.
In the recent years, the increasing applications of brain-computer interface (BCI) in rehabilitation programs have enhanced the chances of functional recovery for patients with neurological disorders. We presented and validated a BCI system with a lower-limb robot for short-term training of patients with spinal cord injury (SCI). The cores of this system included: (1) electroencephalogram (EEG) features related to motor intention reported through experiments and used to drive the robot; (2) a decision tree to determine the training mode provided for patients with different degrees of injuries. Seven SCI patients (one American Spinal Injury Association Impairment Scale (AIS) A, three AIS B, and three AIS C) participated in the short-term training with this system. All patients could learn to use the system rapidly and maintained a high intensity during the training program. The strength of the lower limb key muscles of the patients was improved. Four AIS A/B patients were elevated to AIS C. The cumulative results indicate that clinical application of the BCI system with lower-limb robot is feasible and safe, and has potentially positive effects on SCI patients.
The online version contains supplementary material available at 10.1007/s11571-022-09801-6.
近年来，脑机接口（BCI）在康复项目中的应用不断增加，提高了神经功能障碍患者功能恢复的机会。我们展示并验证了一种用于脊髓损伤（SCI）患者短期训练的带有下肢机器人的BCI系统。该系统的核心包括：（1）通过实验报告的与运动意图相关的脑电图（EEG）特征，并用于驱动机器人；（2）一个决策树，用于确定为不同损伤程度的患者提供的训练模式。七名SCI患者（一名美国脊髓损伤协会损伤分级（AIS）A级、三名AIS B级和三名AIS C级）参与了该系统的短期训练。所有患者都能迅速学会使用该系统，并在训练过程中保持高强度。患者下肢关键肌肉的力量得到了改善。四名AIS A/B级患者提升至AIS C级。累积结果表明，带有下肢机器人的BCI系统的临床应用是可行且安全的，对SCI患者具有潜在的积极影响。
在线版本包含可在10.1007/s11571-022-09801-6获取的补充材料。
