Acharya Anirudh B, Chandrashekar Apoorva, Acharya Swetha, Shettar Leena, Thakur Srinath
Department of Periodontics, S.D.M. College of Dental Sciences & Hospital, Dharwad, 580009, Karnataka, India.
Department of Periodontics, A.J. Shetty Institute of Dental Sciences, Mangalore, 575004, Karnataka, India.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1609-1613. doi: 10.1016/j.dsx.2019.03.027. Epub 2019 Mar 18.
The two-way relationship between diabetes mellitus and periodontitis has been extensively studied with various interconnected biomarkers sharing a link. Soluble Tumour Necrosis Factor-like Weak inducer of apoptosis (sTWEAK) is gaining attention as an important mediator in chronic inflammatory diseases. Thus, the aim of this study was to detect, estimate and compare the levels of sTWEAK in the serum of health, chronic periodontitis (CP), and CP with type 2 diabetes mellitus (T2DM).
Forty-five participants between 18 and 65 years were divided into groups of 15 each as Group 1: healthy, Group 2: CP, and Group 3: CP + T2DM. Clinical periodontal parameters and glycemic status were assessed. sTWEAK in serum was estimated using a commercially available ELISA kit. The data was statistically analyzed.
sTWEAK was detected in all participants. Significant differences were observed between the groups for sTWEAK; highest in health, lower in CP and lowest in CP + T2DM. In the diseased groups, the clinical and glycemic parameters correlated positively with each other, whereas sTWEAK correlated negatively with each of the parameters.
The literature reports lower concentrations of systemic sTWEAK in T2DM which may be comparable to our observations in CP + T2DM when compared to health and its negative correlation with all the parameters suggesting an association with both clinical periodontal parameters and glycemic levels. However, serum sTWEAK levels may not be necessarily elevated in periodontitis as previously reported, and hence has the potential to be studied extensively for clarification with its association with T2DM.
糖尿病与牙周炎之间的双向关系已通过各种相互关联的生物标志物进行了广泛研究。可溶性肿瘤坏死因子样凋亡弱诱导剂（sTWEAK）作为慢性炎症性疾病中的一种重要介质正受到关注。因此，本研究的目的是检测、评估和比较健康人、慢性牙周炎（CP）患者以及合并2型糖尿病（T2DM）的CP患者血清中sTWEAK的水平。
将45名年龄在18至65岁之间的参与者分为三组，每组15人，分别为：第1组：健康组；第2组：CP组；第3组：CP + T2DM组。评估临床牙周参数和血糖状况。使用市售ELISA试剂盒评估血清中的sTWEAK。对数据进行统计学分析。
所有参与者均检测到sTWEAK。各组之间sTWEAK存在显著差异；健康组最高，CP组较低，CP + T2DM组最低。在患病组中，临床和血糖参数呈正相关，而sTWEAK与每个参数均呈负相关。
文献报道T2DM患者体内系统性sTWEAK浓度较低，与健康组相比可能与我们在CP + T2DM组中的观察结果相当，且其与所有参数呈负相关，表明与临床牙周参数和血糖水平均有关联。然而，血清sTWEAK水平可能并不像先前报道的那样在牙周炎中必然升高，因此有必要对其与T2DM的关联进行广泛研究以加以澄清。
