Arshad Rizwan, Sameen Aysha, Murtaza Mian Anjum, Sharif Hafiz Rizwan, Dawood Sahifa, Ahmed Zahoor, Nemat Arash, Manzoor Muhammad Faisal
University Institute of Diet and Nutritional Sciences The University of Lahore Gujrat Campus Gujrat Pakistan.
National Institute of Food Science and Technology University of Agriculture Faisalabad Faisalabad Pakistan.
Food Sci Nutr. 2022 Jul 7;10(10):3230-3240. doi: 10.1002/fsn3.2948. eCollection 2022 Oct.
The role of vitamin D in improving maternal health and reducing the risk of developmental disorders in fetus has been an important domain of research since the past few years. Vitamin D, owing to its immunomodulatory, anti-inflammatory, developmental roles, and regulating calcium homeostasis, is predicted to have a significant influence on maternal and fetal health status. Several observational studies and clinical trials, determining the impact of vitamin D on gestational diabetes, C-section, postpartum depression, pre-eclampsia, miscarriages, and preterm delivery, have been elaborated in this review. In addition, fetal birth defects including neurological development, reduced birth weight, respiratory infections, bone development, and altered anthropometrics have also been summarized with available evidences. Other important mechanisms related to the roles of vitamin D in the body are also explained. Furthermore, recent studies determining the effect of vitamin D at genetic level will also help in understanding and future design of research in the area of maternal and fetal health.
过去几年以来,维生素D在改善孕产妇健康以及降低胎儿发育障碍风险方面的作用一直是一个重要的研究领域。维生素D具有免疫调节、抗炎、发育以及调节钙稳态等作用,预计会对母婴健康状况产生重大影响。本综述阐述了多项观察性研究和临床试验,这些研究确定了维生素D对妊娠期糖尿病、剖宫产、产后抑郁、先兆子痫、流产和早产的影响。此外,还利用现有证据总结了包括神经发育、低出生体重、呼吸道感染、骨骼发育和人体测量学改变在内的胎儿出生缺陷。文中还解释了与维生素D在体内作用相关的其他重要机制。此外,近期在基因水平上确定维生素D作用效果的研究也将有助于理解母婴健康领域的研究并为未来该领域的研究设计提供帮助。