Department of Surgery and Surgical Nursery with a Research Laboratory and Genetic Laboratory, Faculty of Medicine and Health Sciences, Jan Kochanowski University, 19, 5-317 Kielce, Poland.
Department of Pathology, Faculty of Medicine and Health Sciences, Jan Kochanowski University, 19, 25-317 Kielce, Poland.
Nutrients. 2019 Jul 22;11(7):1682. doi: 10.3390/nu11071682.
It is postulated that both individual genotype and environmental factors such as diet may modify the risk of developing colorectal cancer (CRC). The influences of gene polymorphism and red meat intake on CRC occurrence in the Polish population were analyzed in this study.
Genotyping was performed with the qPCR method.
A high frequency of meat consumption was associated with an over 2-fold increase in the risk of colorectal cancer odds ratio (OR) adjusted for sex and age = 2.4, 95% confidence interval (CI); 1.3-4.4). However, after analyzing the genetic profiles, in the absence of polymorphisms of all three analyzed genes, there was no association between a high frequency of meat consumption and the occurrence of CRC. In the case of gene polymorphism, the high frequency of meat consumption increased the risk of CRC by almost more than 4 times (OR adjusted for sex and age = 3.8, 95% CI: 1.6-9.1). For gene polymorphism, a 3-fold increase in CRC risk was observed with a high frequency of meat consumption (OR adjusted for sex and age = 3.4, 95% CI: 1.4-8.1). In the case of gene polymorphism, the increase in risk of CRC was not statistically significant (OR adjusted for sex and age = 1.9, 95% CI: 0.4-8.5).
The frequency of red meat intake in non-smokers increases the risk of colon cancer in the case of gene polymorphisms.
据推测，个体基因型和环境因素（如饮食）都可能改变结直肠癌（CRC）的发病风险。本研究分析了基因多态性和红肉摄入对波兰人群 CRC 发生的影响。
采用 qPCR 方法进行基因分型。
高频率的肉类消费与结直肠癌风险增加 2 倍以上相关（调整性别和年龄后的比值比[OR] = 2.4，95%置信区间[CI]：1.3-4.4）。然而，在分析遗传特征后，在不存在所有三个分析基因的多态性的情况下，高频率的肉类消费与 CRC 的发生之间没有关联。在基因多态性的情况下，高频率的肉类消费使 CRC 的发病风险增加了近 4 倍（调整性别和年龄后的比值比[OR] = 3.8，95%CI：1.6-9.1）。对于 基因多态性，高频率的肉类消费使 CRC 的发病风险增加了 3 倍（调整性别和年龄后的比值比[OR] = 3.4，95%CI：1.4-8.1）。对于 基因多态性，CRC 发病风险的增加无统计学意义（调整性别和年龄后的比值比[OR] = 1.9，95%CI：0.4-8.5）。
非吸烟者中红肉摄入的频率增加了 基因多态性情况下结肠癌的风险。
