源自夏威夷内生真菌拟盘多毛孢属真菌FT172的抗增殖安布酸衍生物。
Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.
作者信息
Li Chun-Shun, Yang Bao-Jun, Turkson James, Cao Shugeng
机构信息
Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
Natural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
出版信息
Phytochemistry. 2017 Aug;140:77-82. doi: 10.1016/j.phytochem.2017.04.017.
Abstract
Five previously undescribed ambuic acid derivatives, pestallic acids A-E and three known analogs were isolated from the cultured broth of Pestalotiopsis sp. FT172. The structures of the pestallic acids A-E were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations (ACs) of pestallic acids B-E were assigned by comparison of the experimental electric circular dichroism (ECD) spectra or the optical rotations with those in the literature. All compounds were tested against A2780 and cisplatin resistant A2780 (A2780CisR) cell lines. Pestallic acid E and (+)-ambuic acid showed potent activities with IC values from 3.3 to 17.0 μM.
摘要
从拟盘多毛孢属真菌FT172的培养液中分离出5种先前未描述过的ambuic酸衍生物、pestallic酸A - E以及3种已知类似物。通过高分辨质谱（HRMS）和核磁共振（NMR）光谱数据分析确定了pestallic酸A - E的结构。通过将实验性圆二色光谱（ECD）或旋光度与文献中的数据进行比较，确定了pestallic酸B - E的绝对构型（ACs）。对所有化合物进行了针对A2780和顺铂耐药的A2780（A2780CisR）细胞系的测试。pestallic酸E和（+）-ambuic酸表现出较强的活性，IC值在3.3至17.0 μM之间。
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