Department of Medical Physics, Tehran University of Medical Sciences (TUMS), Tehran 1416753955, Iran.
Department of Physics, University of Guilan, Guilan 43714, Iran.
Medicina (Kaunas). 2019 Jul 12;55(7):370. doi: 10.3390/medicina55070370.
: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and www.ClinicalTrials.gov for information about completed or ongoing clinical trials. From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case-control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights.
电离辐射（IR）对人类有巨大的益处，特别是在医学用途（诊断成像和放射治疗）方面。然而，健康正常细胞的毒性风险，导致细胞损伤以及早期和晚期副作用，一直是主要的缺点。本研究旨在评估橙皮苷对 IR 诱导损伤的放射保护作用。本研究报告遵循系统评价和荟萃分析的首选报告项目（PRISMA）。使用电子数据库 PubMed、Scopus、Embase、Google Scholar 和 www.ClinicalTrials.gov 搜索已完成或正在进行的临床试验的信息。根据我们的搜索结果，纳入了 24 项涉及大鼠、小鼠以及培养的人和动物细胞的研究。所有研究均采用实验病例对照设计。研究表明，橙皮苷的给药可减轻所有研究组织中的氧化应激和炎症。此外，它还提高了 30 天和 60 天的存活率，并能预防 DNA 损伤。在照射前给予橙皮苷可获得最佳的放射保护作用。纳入研究的结果支持橙皮苷作为一种潜在的放射保护剂，具有抗氧化、抗炎和抗细胞凋亡的能力，可抵抗 IR 诱导的损伤。我们建议进行未来的临床试验以获得更多的见解。
