NONRATT021972 长链非编码 RNA：糖尿病相关疾病中有前途的 lncRNA。
NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases.
机构信息
Department of Ophthalmology, The First Hospital of Jilin University, No. 71 of Xinmin St., Changchun, Jilin Province, 130021, China.
Department of Radiology, The First Hospital of Jilin University, No. 71 of Xinmin St., Changchun, Jilin Province, 130021, China.
出版信息
Int J Med Sci. 2019 Jun 2;16(6):902-908. doi: 10.7150/ijms.34200. eCollection 2019.
Diabetes mellitus (DM) is a principal health problem with increasing incidence worldwide. It can be associated with various systemic diseases. Long non-coding RNA (lncRNA), a member of non-coding RNA has been newly linked with various human diseases. Recent evidence from animal experiments has shown that the incidence and development of type 2 diabetes are contributed by the atypical expression of lncRNA in which the biomarker with capable clinical potential was lncRNA NONRATT021972. In this review, we demonstrated the numerous functions of NONRATT021972 in different diabetes-related diseases including diabetic neuropathy, diabetic cardiac autonomic neuropathy, myocardial ischemia, and hepatic glucokinase dysfunction. The emerging evidence shows that the role of NONRATT021972 in diabetic-related disease is novel and therapeutic. These results direct us to conclude that NONRATT021972 is a potential diagnostic and future targeted therapy for diabetes-associated diseases.
糖尿病（DM）是一个全球性的主要健康问题，发病率不断上升。它可能与各种系统性疾病有关。长链非编码 RNA（lncRNA）是一种非编码 RNA 的成员，与各种人类疾病有关。最近的动物实验证据表明，2 型糖尿病的发生和发展是由 lncRNA 的非典型表达引起的，其中具有潜在临床应用价值的生物标志物是 lncRNA NONRATT021972。在本综述中，我们展示了 NONRATT021972 在不同糖尿病相关疾病中的多种功能，包括糖尿病性神经病、糖尿病性心脏自主神经病、心肌缺血和肝葡萄糖激酶功能障碍。新出现的证据表明，NONRATT021972 在糖尿病相关疾病中的作用是新颖和治疗性的。这些结果使我们得出结论，NONRATT021972 是一种潜在的与糖尿病相关疾病的诊断和未来靶向治疗的候选物。
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