Duanmu Zheng, Chen Weiwei, Gao Hao, Yang Xilan, Luo Xiaoyu, Hill Nicholas A
Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument, Beijing Information Science and Technology University, Beijing, China.
Guangxi Key Laboratory of Regenerative Medicine, Research Centre for Regenerative Medicine, Guangxi Medical University, Guangxi, China.
Front Physiol. 2019 Jul 9;10:853. doi: 10.3389/fphys.2019.00853. eCollection 2019.
One-dimensional (1D) hemodynamic models of arteries have increasingly been applied to coronary circulation. In this study, we have adopted flow and pressure profiles in Olufsen's 1D structured tree as coronary boundary conditions, with terminals coupled to the dynamic pressure feedback resulting from the intra-myocardial stress because of ventricular contraction. We model a trifurcation structure of the example coronary tree as two adjacent bifurcations. The estimated results of blood pressure and flow rate from our simulation agree well with the clinical measurements and published data. Furthermore, the 1D model enables us to use wave intensity analysis to simulate blood flow in the developed coronary model. Six characteristic waves are observed in both left and right coronary flows, though the waves' magnitudes differ from each other. We study the effects of arterial wall stiffness on coronary blood flow in the left circumflex artery (LCX). Different diseased cases indicate that distinct pathological reactions of the cardiovascular system can be better distinguished through Wave Intensity analysis, which shows agreement with clinical observations. Finally, the feedback pressure in terminal vessels and measurement deviation are also investigated by changing parameters in the LCX. We find that larger feedback pressure increases the backward wave and decreases the forward one. Although simplified, this 1D model provides new insight into coronary hemodynamics in healthy and diseased conditions. We believe that this approach offers reference resources for studies on coronary circulation disease diagnosis, treatment and simulation.
一维（1D）动脉血流动力学模型已越来越多地应用于冠状动脉循环。在本研究中，我们采用了奥卢夫森一维结构化树中的血流和压力分布作为冠状动脉边界条件，其末端与心室收缩引起的心肌内应力产生的动态压力反馈相耦合。我们将示例冠状动脉树的三叉结构建模为两个相邻的分支。我们模拟得到的血压和流速估计结果与临床测量值和已发表数据吻合良好。此外，一维模型使我们能够使用波强度分析来模拟已构建的冠状动脉模型中的血流。在左、右冠状动脉血流中均观察到六个特征波，尽管这些波的幅度彼此不同。我们研究了动脉壁硬度对左旋支动脉（LCX）冠状动脉血流的影响。不同的病变病例表明，通过波强度分析可以更好地区分心血管系统不同的病理反应，这与临床观察结果一致。最后，我们还通过改变LCX中的参数研究了末梢血管中的反馈压力和测量偏差。我们发现较大的反馈压力会增加反向波并减小正向波。尽管该一维模型较为简化，但它为健康和患病状态下的冠状动脉血流动力学提供了新的见解。我们相信这种方法为冠状动脉循环疾病的诊断、治疗和模拟研究提供了参考资源。
