Neininger Martina P, Buchholz Patricia, Frontini Roberto, Kiess Wieland, Siekmeyer Werner, Bertsche Astrid, Siekmeyer Manuaela, Bertsche Thilo
Department of Clinical Pharmacy and Drug Safety Center, Leipzig University, Leipzig, Germany.
Pharmacy Department of the University Hospital Leipzig and Drug Safety Center, Leipzig University, Leipzig, Germany.
Eur J Hosp Pharm. 2019 Jul;26(4):214-217. doi: 10.1136/ejhpharm-2017-001248. Epub 2017 Jul 24.
To identify incompatible intravenous drug combinations in routine paediatric intensive care and evaluate physician and nurse knowledge.
In a university paediatric intensive care unit, intravenous drug incompatibilities were analysed using a database and physician and nurse knowledge of incompatibilities was assessed using a questionnaire.
We analysed 665 prescriptions in 87 patients. Incompatible drug administration was identified in 9 (10%) of the 87 patients with a median of 3 different incompatibilities per patient (Q25/Q75: 1/3). We found 26 incompatible combinations. The most frequently involved drugs were cefotaxime, pantoprazole and vancomycin. A median of 10 of the 15 drug combinations were correctly assessed as compatible or incompatible (Q25/Q75: 8/11). Pantoprazole had a low number (20%) of correct answers.
One in 10 patients in paediatric intensive care was affected by drug incompatibility, with knowledge deficits seen in a third of assessed combinations. This indicates quality improvement strategies should be urgently implemented by pharmacists.
确定儿科重症监护常规治疗中不相容的静脉药物组合，并评估医生和护士的相关知识。
在一所大学的儿科重症监护病房，利用数据库分析静脉药物不相容性，并通过问卷调查评估医生和护士对不相容性的了解。
我们分析了87例患者的665份处方。87例患者中有9例（10%）出现药物不相容给药情况，每位患者的不相容情况中位数为3种（四分位数间距：1/3）。我们发现了26种不相容组合。涉及最多的药物是头孢噻肟、泮托拉唑和万古霉素。15种药物组合中，有10种组合的相容性或不相容性评估正确的中位数为10（四分位数间距：8/11）。泮托拉唑的正确答案比例较低（20%）。
儿科重症监护中每10名患者中有1名受到药物不相容性影响，三分之一的评估组合存在知识缺陷。这表明药剂师应紧急实施质量改进策略。
