非编码 RNA 与神经炎症：对卒中治疗的启示。
Non-coding RNA and neuroinflammation: implications for the therapy of stroke.
机构信息
Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
出版信息
Stroke Vasc Neurol. 2019 Mar 2;4(2):96-98. doi: 10.1136/svn-2018-000206. eCollection 2019 Jul.
Abstract
Stroke is the major leading cause of death and serious, long-term disability with major economic consequences. At present, the lack of rapid diagnostic, prognostic biomarkers and effective treatment methods are two major challenges facing stroke. Circular RNAs (circRNAs) are potential clinical biomarkers in central nervous system diseases. However, the potential role of circRNAs in neuroinflammation and neuron functional recovery in acute ischaemic stroke (AIS) remains largely unknown. This review aimed to give an overview of the function of circRNAs in AIS and summarise the latest achievements in this field.
摘要
中风是主要的死亡原因和严重的长期残疾，具有重大的经济后果。目前，缺乏快速诊断、预后生物标志物和有效的治疗方法是中风面临的两大挑战。环状 RNA（circRNAs）是中枢神经系统疾病有潜力的临床生物标志物。然而，circRNAs 在急性缺血性中风（AIS）中的神经炎症和神经元功能恢复中的潜在作用在很大程度上仍然未知。本综述旨在概述 circRNAs 在 AIS 中的作用，并总结该领域的最新研究成果。
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