Cheng Liuyang, Liu Zeyu, Xia Jian
Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, P.R. China.
Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, China.
Mol Biol Rep. 2023 Jan;50(1):829-840. doi: 10.1007/s11033-022-07949-2. Epub 2022 Nov 4.
Ischemic stroke accounts for about 71% of strokes worldwide. Due to limited recommended therapeutics for ischemic stroke, more attention is focused on angiogenesis in ischemic stroke. Not long after ischemic stroke, angiogenesis arises and is vital for the prognosis. Various pro-angiogenic, anti-angiogenic factors and their downstream pathways engage in angiogenesis regulation. CircRNAs are differentially expressed after ischemic stroke. Up to now, circRNAs have been found to exert many functions in regulating apoptosis, autophagy, proliferation, and differentiation of neurons and neural stem cells mainly as miRNAs sponges or proteins decoy. Thus, many circRNAs are considered promising biomarkers or therapeutic targets for ischemic stroke. Besides, circRNAs participate in the modulation of endothelial-mesenchymal transition and blood-brain barrier maintenance. Moreover, circRNAs play significant roles in endothelial dysfunction concerning inflammation responses, apoptosis, proliferation, and migration. They correlate with many angiogenesis-related signaling pathways and genes via the circRNA/miRNA/mRNA network. Novel insights into circRNAs significance in angiogenesis regulation in ischemic stroke could be provided for further researches on the clinical application of circRNAs in ischemic stroke.
缺血性中风约占全球中风病例的71%。由于缺血性中风的推荐治疗方法有限，更多的注意力集中在缺血性中风中的血管生成上。缺血性中风后不久，血管生成就会出现，并且对预后至关重要。各种促血管生成、抗血管生成因子及其下游途径参与血管生成调节。缺血性中风后环状RNA（circRNAs）存在差异表达。到目前为止，已发现circRNAs主要作为微小RNA（miRNAs）海绵或蛋白质诱饵，在调节神经元和神经干细胞的凋亡、自噬、增殖和分化中发挥多种功能。因此，许多circRNAs被认为是缺血性中风有前景的生物标志物或治疗靶点。此外，circRNAs参与内皮-间充质转化的调节和血脑屏障的维持。此外，circRNAs在涉及炎症反应、凋亡、增殖和迁移的内皮功能障碍中起重要作用。它们通过circRNA/miRNA/信使核糖核酸（mRNA）网络与许多血管生成相关信号通路和基因相关联。对于circRNAs在缺血性中风血管生成调节中的意义的新见解，可为进一步研究circRNAs在缺血性中风中的临床应用提供依据。
