急性髓系白血病和白血病干细胞中的表观遗传学异常。

Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells.

机构信息

Department of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Adv Exp Med Biol. 2019;1143:173-189. doi: 10.1007/978-981-13-7342-8_8.

DOI:10.1007/978-981-13-7342-8_8

PMID:31338820

Abstract

Recently advances in cancer genomics revealed the unexpected high frequencies of epigenetic abnormalities in human acute myeloid leukemia (AML). Accumulating data suggest that these leukemia-associated epigenetic factors play critical roles in both normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs). In turn, these abnormalities result in susceptibilities of LSC and related diseases to epigenetic inhibitors. In this chapter, we will focus on the mutations of epigenetic factors in AML, their functional roles and mechanisms in normal hematopoiesis and leukemia genesis, especially in LSC, and potential treatment opportunities specifically for AML with epigenetic dysregulations.

摘要

最近癌症基因组学的进展揭示了人类急性髓细胞白血病 (AML) 中表观遗传学异常的高频率，这令人意外。越来越多的证据表明，这些与白血病相关的表观遗传因素在正常造血干细胞 (HSCs) 和白血病干细胞 (LSCs) 中都发挥着关键作用。反过来，这些异常导致 LSC 及其相关疾病对表观遗传抑制剂的敏感性。在本章中，我们将重点讨论 AML 中表观遗传因子的突变及其在正常造血和白血病发生中的功能作用和机制，特别是在 LSC 中，以及针对表观遗传失调的 AML 的潜在治疗机会。