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胚胎组织残留行子宫动脉栓塞术后的并发症及生殖结局

Complications and reproductive outcome after uterine artery embolization for retained products of conception.

作者信息

Ohmaru-Nakanishi Takako, Kuramoto Kazutaka, Maehara Miyako, Takeuchi Reiko, Oishi Hiroko, Ueoka Yosuke

机构信息

Department of Obstetrics and Gynecology, Hamanomachi Hospital, Fukuoka, Japan.

出版信息

J Obstet Gynaecol Res. 2019 Oct;45(10):2007-2014. doi: 10.1111/jog.14067. Epub 2019 Jul 23.

Abstract

AIM

The purpose of this study was to evaluate the complications and reproductive outcome after uterine artery embolization (UAE) for retained products of conception (RPOC).

METHODS

This was a retrospective medical-records review study of 57 women treated for RPOC. Participants were divided into two groups: women who underwent treatment with UAE (UAE group: n = 32, 56.1%) and those without UAE (control group: n = 25, 43.9%). The complications and reproductive outcomes were compared between the two groups. Information on subsequent pregnancies and their outcomes was available for 30 women who attempted to conceive.

RESULTS

There were no significant differences in the interval from the last delivery or abortion (40.1 ± 3.4 vs 51.0 ± 5.1 months, respectively; P = 0.16), the rate of severe bleeding under hysteroscopy (18.5 vs 9.1%, respectively; P = 0.65), the conception rate (58.8 vs 61.5%, respectively; P = 1.0) and mean time to conception (9.9 ± 1.6 vs 11.0 ± 2.9 months, respectively; P = 0.17) in women in the UAE group compared with those in the control group. Rates of post-partum hemorrhage (PPH) and manual removal of placenta (25.0% in the UAE group and 16.7% in the control group, respectively) were higher than the general population.

CONCLUSION

Selective UAE for RPOC may be a preferable procedure in women who are suspected as having a risk of severe bleeding under treatment. Women who were treated for RPOC, regardless of UAE, were at risk of PPH and difficulty in removing the placenta in future pregnancies.

摘要

目的

本研究旨在评估子宫动脉栓塞术(UAE)治疗稽留流产(RPOC)后的并发症及生殖结局。

方法

这是一项对57例接受RPOC治疗的女性进行的回顾性病历审查研究。参与者分为两组:接受UAE治疗的女性(UAE组:n = 32,56.1%)和未接受UAE治疗的女性(对照组:n = 25,43.9%)。比较两组的并发症和生殖结局。30名尝试受孕的女性可获得后续妊娠及其结局的信息。

结果

与对照组相比,UAE组女性末次分娩或流产后的时间间隔(分别为40.1±3.4个月和51.0±5.1个月;P = 0.16)、宫腔镜检查下严重出血率(分别为18.5%和9.1%;P = 0.65)、受孕率(分别为58.8%和61.5%;P = 1.0)及平均受孕时间(分别为9.9±1.6个月和11.0±2.9个月;P = 0.17)均无显著差异。产后出血(PPH)和人工剥离胎盘的发生率(UAE组为25.0%,对照组为16.7%)高于一般人群。

结论

对于怀疑治疗时有严重出血风险的女性,选择性UAE治疗RPOC可能是一种较好的方法。无论是否接受UAE治疗,接受RPOC治疗的女性未来妊娠均有PPH风险及胎盘剥离困难。

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