Liu Ailing, Wan Ailing, Feng Aifang, Rui Ruping, Zhou Bingzhi
Department of Emergency.
Outpatient Department, Yidu Central Hospital of Weifang, Shandong.
Medicine (Baltimore). 2018 Oct;97(40):e12523. doi: 10.1097/MD.0000000000012523.
Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent.
To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI).
In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD.
许多研究调查了细胞间黏附分子1（ICAM-1）基因rs5498多态性与冠状动脉疾病（CAD）风险之间的关联。然而，结果并不一致。
为了明确令人信服的关联，我们通过检索PubMed、Embase、科学网、科学引文索引、谷歌学术、Cochrane图书馆和中国知网数据库进行了一项全面的荟萃分析。计算合并比值比（OR）和95%置信区间（CI）。
总共纳入了29项关于rs5498多态性的病例对照研究，其中病例5494例，对照6364例。本荟萃分析的研究人群包括白种人和亚洲人。荟萃分析表明，rs5498多态性与CAD风险降低有关。种族分层分析发现，rs5498多态性降低了白种人患CAD的风险，但在亚洲人中没有。按CAD类型分层显示，ICAM-1基因rs5498多态性也与心肌梗死（MI）风险降低相关。
总之，这项荟萃分析表明，ICAM-1基因rs5498多态性降低了CAD的风险。
