免疫功能正常患者玻璃体内植入地塞米松后发生的巨细胞病毒性视网膜炎
CYTOMEGALOVIRUS RETINITIS AFTER AN INTRAVITREAL DEXAMETHASONE IMPLANT IN AN IMMUNOCOMPETENT PATIENT.
作者信息
Witmer Matthew T, Connolly Brian P
机构信息
Retina Associates of Western New York, Rochester, New York.
出版信息
Retin Cases Brief Rep. 2021 Nov 1;15(6):670-672. doi: 10.1097/ICB.0000000000000904.
PURPOSE
To present the case of a 71-year-old woman who developed cytomegalovirus retinitis after the administration of an intravitreal dexamethasone implant in an immunocompetent patient.
METHODS
Retrospective case report.
PATIENTS
Single patient with a diagnosis of cytomegalovirus retinitis associated with the intravitreal dexamethasone implant.
RESULTS
The patient developed cytomegalovirus retinitis three months after an intravitreal injection of a dexamethasone implant for macular edema. The patient had no history of poor immune function and was not taking immunosuppressive medications.
CONCLUSION
Cytomegalovirus retinitis has been associated with local steroid therapy. This has been described in both immunocompromised and immunocompetent patients. The intravitreal dexamethasone implant may cause local immunosuppression and result in cytomegalovirus retinitis in immunocompetent patients.
目的
报告一例71岁免疫功能正常的女性患者在玻璃体内注射地塞米松植入剂后发生巨细胞病毒性视网膜炎的病例。
方法
回顾性病例报告。
患者
一名诊断为与玻璃体内地塞米松植入剂相关的巨细胞病毒性视网膜炎的患者。
结果
该患者在玻璃体内注射地塞米松植入剂治疗黄斑水肿三个月后发生巨细胞病毒性视网膜炎。患者既往无免疫功能低下病史，未服用免疫抑制药物。
结论
巨细胞病毒性视网膜炎与局部类固醇治疗有关。免疫功能低下和免疫功能正常的患者均有相关报道。玻璃体内地塞米松植入剂可能导致局部免疫抑制，并在免疫功能正常的患者中引发巨细胞病毒性视网膜炎。
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