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巴西伯南布哥州艾滋病毒/艾滋病患者中人类嗜T淋巴细胞病毒1型/2型的流行情况及危险因素

HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil.

作者信息

Ribeiro Mirela Lopes, Gonçales Juliana Prado, Morais Viviane Martha Santos de, Moura Libia Cristina Rocha Vilela, Coêlho Maria Rosângela Cunha Duarte

机构信息

Setor de Virologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Departamento de Medicina Tropical, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, Brasil.

出版信息

Rev Soc Bras Med Trop. 2019 Jul 18;52:e20180244. doi: 10.1590/0037-8682-0244-2018.

DOI:10.1590/0037-8682-0244-2018
PMID:31340354
Abstract

INTRODUCTION

Apart from masking the diagnosis of AIDS in patients with HIV/AIDS, human T-cell lymphotropic virus (HTLV), when present, also increases the risk of myelopathies and neurological disease in these patients.

METHODS

Disease prevalence was estimated by ELISA and confirmed by Western blot.

RESULTS

The coinfection rate was 1.5% (11/720); 10 of 11 patients had HTLV-1, and the remaining one had HTLV-2. The majority were male, over 40 years old, and of pardo color (ethnicity).

CONCLUSIONS

There was no association between the risk factors examined and HTLV/HIV coinfection. This is the first study to report the occurrence of HTLV-2 in Pernambuco.

摘要

引言

除了掩盖人类免疫缺陷病毒/艾滋病(HIV/AIDS)患者的艾滋病诊断外,人类嗜T淋巴细胞病毒(HTLV)一旦存在,也会增加这些患者患脊髓病和神经疾病的风险。

方法

通过酶联免疫吸附测定(ELISA)估计疾病患病率,并通过蛋白质印迹法进行确认。

结果

合并感染率为1.5%(11/720);11名患者中有l0名感染了HTLV-1,其余1名感染了HTLV-2。大多数患者为男性,年龄超过40岁,肤色为帕尔多人(种族)。

结论

所检查的危险因素与HTLV/HIV合并感染之间无关联。这是第一项报告伯南布哥州出现HTLV-2感染情况的研究。

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