Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Qingdao Women and Children's Hospital, Qingdao University, Qingdao, 266011, Shandong, China.
BMC Public Health. 2019 Jul 24;19(1):991. doi: 10.1186/s12889-019-7324-x.
High-sensitivity C-reactive protein (hs-CRP) is a common risk factor for developing cardiovascular disease. However, there has been no study reporting the relationship between hs-CRP and blood pressure in Yi adults. The aim of this study is to investigate the association between hs-CRP and blood pressure in Yi adults.
In this cross-sectional study, included subjects were 2916 Yi migrants or farmers aged 20-80 years, recruited by using a stratified cluster sampling method from Liangshan Yi Autonomous Prefecture of Sichuan Province in 2014. The directed acyclic graphs(DAG) was used to select a minimal sufficient adjustment sets of variables which would identification the unconfounded effect of hs-CRP and hypertension. Multiple linear and multinomial logit analysis were used to estimate the effect of hs-CRP on SBP/DBP/MAP/PP and the prevalence of prehypertension/hypertension after adjustment for the relevant confounders.
The median level of hs-CRP was 1.20 (0.50-3.06)mg/L in Yi migrants, and 0.84(0.36-2.52) mg/L in Yi farmers, and the prevalence of high hs-CRP was 23.25%. For hs-CRP > 3 mg/L group, the adjusted PP tended to have lower values (β = - 1.49, 95%CI: - 2.49--0.49, P = 0.0034) compared with < 1 mg/L group. After adjusting for confounders, there were no significant association between hs-CRP and prehypertension/hypertension (P > 0.05).
Our results suggest that high hs-CRP is prevalent in Yi people, and this study does not support hs-CRP as a risk factor of prehypertension or hypertension.
高敏 C 反应蛋白（hs-CRP）是发生心血管疾病的常见危险因素。然而，目前尚无研究报道 hs-CRP 与彝族成年人血压之间的关系。本研究旨在探讨 hs-CRP 与彝族成年人血压之间的关系。
在这项横断面研究中，纳入了 2014 年采用分层聚类抽样方法从四川省凉山彝族自治州招募的 2916 名彝族移民或农民，年龄在 20-80 岁之间。有向无环图（DAG）用于选择最小充分调整变量集，以识别 hs-CRP 和高血压之间无混杂影响的因素。多线性和多项逻辑回归分析用于估计 hs-CRP 对 SBP/DBP/MAP/PP 的影响，以及调整相关混杂因素后高血压前期/高血压的患病率。
彝族移民 hs-CRP 的中位数水平为 1.20（0.50-3.06）mg/L，彝族农民为 0.84（0.36-2.52）mg/L，hs-CRP 升高的患病率为 23.25%。对于 hs-CRP>3mg/L 组，调整后的脉压（PP）值趋于较低（β=-1.49，95%CI：-2.49--0.49，P=0.0034）。在调整混杂因素后，hs-CRP 与高血压前期/高血压之间无显著相关性（P>0.05）。
我们的研究结果表明，hs-CRP 在彝族人群中较为常见，但不能支持 hs-CRP 是高血压前期或高血压的危险因素。
