Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Future Oncol. 2019 Aug;15(24):2873-2885. doi: 10.2217/fon-2019-0232. Epub 2019 Jul 25.
Despite the numerous publications regarding the role of Epstein-Barr virus (EBV) in breast cancer development, the topic has still remained controversial. The aim of the meta-analysis was to estimate the overall prevalence of EBV in the breast cancer population, and to investigate the association between EBV and breast cancer risk. The overall prevalence of EBV was calculated 26.37% (95% CI: 22-31%) from the 44 included studies. Meta-analysis of 30 case-control studies showed that the pooled association between EBV and risk of breast cancer is odds ratio 4.74 (95% CI: 2.92-7.69; Z = 6.30; p < 0.0001). Our analyses indicate a strong statistical relationship between EBV infection and risk of breast cancer, suggesting a potential role of EBV infection in the development of breast cancer.
尽管有大量关于 Epstein-Barr 病毒（EBV）在乳腺癌发展中的作用的出版物，但这个话题仍然存在争议。本荟萃分析的目的是估计 EBV 在乳腺癌人群中的总体流行率，并探讨 EBV 与乳腺癌风险之间的关联。从 44 项纳入的研究中计算出 EBV 的总体流行率为 26.37%（95%CI：22-31%）。对 30 项病例对照研究的荟萃分析表明，EBV 与乳腺癌风险之间的 pooled 关联是优势比 4.74（95%CI：2.92-7.69；Z=6.30；p<0.0001）。我们的分析表明 EBV 感染与乳腺癌风险之间存在强烈的统计学关系，提示 EBV 感染在乳腺癌的发生发展中可能起作用。
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