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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Renwick A G, Thakrar A, Lawrie C A, George C F

Clinical Pharmacology Group, University of Southampton, UK.

Hum Toxicol. 1988 May;7(3):267-72. doi: 10.1177/096032718800700307.

Indole, p-cresol and phenol are microbial amino acid metabolites which show co-carcinogenic or promoting activity in animal studies. Their involvement in the development of human bladder cancer has been determined by measuring the urinary excretion of indican (indoxyl sulphate) and conjugated phenols. 2. Thirty-two patients (22 males, 10 females) with histologically confirmed carcinoma of the urinary bladder and a similar number of age and sex matched controls took part in the study. The excretion of indican, p-cresol and phenol showed wide interindividual variability, but did not differ significantly between the two groups. 3. The findings indicate that these endogenous metabolites do not contribute significantly to the development of human bladder cancer.

吲哚、对甲酚和苯酚是微生物氨基酸代谢产物，在动物研究中显示出协同致癌或促癌活性。通过测量尿蓝母（硫酸吲哚酚）和结合酚的尿排泄量，已确定它们与人类膀胱癌发展的关联。2. 32例经组织学确诊为膀胱癌的患者（22例男性，10例女性）以及数量相近、年龄和性别匹配的对照组参与了该研究。尿蓝母、对甲酚和苯酚的排泄量在个体间存在很大差异，但两组之间无显著差异。3. 研究结果表明，这些内源性代谢产物对人类膀胱癌的发展贡献不大。

Renwick A G, Thakrar A, Lawrie C A, George C F

Clinical Pharmacology Group, University of Southampton, UK.

Hum Toxicol. 1988 May;7(3):267-72. doi: 10.1177/096032718800700307.

Indole, p-cresol and phenol are microbial amino acid metabolites which show co-carcinogenic or promoting activity in animal studies. Their involvement in the development of human bladder cancer has been determined by measuring the urinary excretion of indican (indoxyl sulphate) and conjugated phenols. 2. Thirty-two patients (22 males, 10 females) with histologically confirmed carcinoma of the urinary bladder and a similar number of age and sex matched controls took part in the study. The excretion of indican, p-cresol and phenol showed wide interindividual variability, but did not differ significantly between the two groups. 3. The findings indicate that these endogenous metabolites do not contribute significantly to the development of human bladder cancer.

吲哚、对甲酚和苯酚是微生物氨基酸代谢产物，在动物研究中显示出协同致癌或促癌活性。通过测量尿蓝母（硫酸吲哚酚）和结合酚的尿排泄量，已确定它们与人类膀胱癌发展的关联。2. 32例经组织学确诊为膀胱癌的患者（22例男性，10例女性）以及数量相近、年龄和性别匹配的对照组参与了该研究。尿蓝母、对甲酚和苯酚的排泄量在个体间存在很大差异，但两组之间无显著差异。3. 研究结果表明，这些内源性代谢产物对人类膀胱癌的发展贡献不大。