Roberts A, Renwick A G
Food Chem Toxicol. 1985 Apr-May;23(4-5):451-5. doi: 10.1016/0278-6915(85)90139-5.
The microbial catabolism of tryptophan to indole has been studied in 15 human subjects by analysis of the daily urinary excretion of indican (potassium indoxylsulphate) before, during and after chronic saccharin ingestion. The daily excretion of indican during a 3-wk control period showed marked inter- and intra-subject variability. Analysis of the urinary excretion of saccharin during chronic administration demonstrated good compliance for both saccharin ingestion and urine collection. The urinary excretion of indican was not increased significantly by the ingestion of saccharin (1 g/day as divided doses with meals) for one month. These findings are consistent with epidemiology studies which show the absence of a consistent excess risk of cancer of the urinary bladder in humans ingesting saccharin as a food additive.
通过分析15名人类受试者在长期摄入糖精之前、期间和之后每日尿中吲哚硫酸盐（硫酸钾吲哚酚）的排泄情况，研究了色氨酸向吲哚的微生物分解代谢。在为期3周的对照期内，吲哚硫酸盐的每日排泄量在个体间和个体内均表现出显著差异。长期给药期间对糖精尿排泄的分析表明，在糖精摄入和尿液收集方面受试者依从性良好。连续一个月摄入糖精（每日1克，分剂量随餐服用）后，吲哚硫酸盐的尿排泄量没有显著增加。这些发现与流行病学研究一致，该研究表明，人类将糖精作为食品添加剂摄入时，不存在一致的膀胱癌额外风险。
