Aarbakke J, Schjönsby H
Scand J Gastroenterol. 1976;11(4):409-14.
The urinary excretion of phenol, p-cresol, and indican was determined in 7 patients with the stagnant loop syndrome, 26 patients with coeliac disease, chronic pancreatitis, and partial gastrectomy, and 18 control patients. The mean excretion of the compounds in the patients with the stagnant loop syndrome and in the control patients, respectively, was 77 and 2.3 mg/24 h of phenol (p less than 0.05), 164 and 39.5 mg/24 h of p-cresol (n.s.), and 369 and 41.5 mg/24 h of indican (p less than 0.01). When applied as diagnostic tests for the stagnant loop syndrome, the phenol excretion showed 2 false negative results, the p-cresol excretion 3 false negative and 2 false positive results, and the indican excretion 6 false positive results. The combined use of phenol and indican determinations eliminated the number of false positive results with the indican test, and was found most useful as screening procedure. Determination of phenol and indican in a 24-hour urine sample is likely to provide a simple method for selecting patients with signs of abnormal bacterial colonization in the small intestine for more detailed investigations.
对7例患有肠袢淤滞综合征的患者、26例患有乳糜泻、慢性胰腺炎和部分胃切除术的患者以及18例对照患者测定了苯酚、对甲酚和吲哚苷的尿排泄量。肠袢淤滞综合征患者和对照患者中这些化合物的平均排泄量分别为：苯酚77和2.3mg/24小时（p<0.05），对甲酚164和39.5mg/24小时（无显著性差异），吲哚苷369和41.5mg/24小时（p<0.01）。当用作肠袢淤滞综合征的诊断试验时，苯酚排泄显示2例假阴性结果，对甲酚排泄显示3例假阴性和2例假阳性结果，吲哚苷排泄显示6例假阳性结果。联合使用苯酚和吲哚苷测定可消除吲哚苷试验的假阳性结果数量，并且被发现作为筛查程序最为有用。测定24小时尿液样本中的苯酚和吲哚苷可能为选择有小肠细菌定植异常迹象的患者进行更详细的检查提供一种简单方法。
