a Department of Neurosurgery, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
b Department of Neurosurgery, Qilu Hospital, Shandong University , Qingdao , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3094-3100. doi: 10.1080/21691401.2019.1637883.
To evaluate the long-term biological and clinical results of anterior cervical corpectomy and fusion (ACCF) with a synthesized nano-graphene oxide (nano-GO) loaded hydroxyapatite/polyamide (HAp/PA) strut in the implantation treatment of cervical reconstruction. Bio-ceramic Hydroxyapatite (HAp) combined with suitable polymer matrix is one of the furthermost naturally occurring biomaterial form for hard tissues and dental regeneration therapies due to their bone-like chemical compositional structure and biocompatibility similarity to native bone of the human body. In the present investigation, the development of nano-GO loaded HAp/PA composite strut for anterior cervical reform and fusion properties after corpectomy is studied. Forty patients who suffered from first or second level ACCF, treated with nano-GO loaded HAp/PA strut, were investigated. At final follow-up period, the fusion rate was 99%, and the subsidence value of the prepared strut was 5%. The results of cell viability and proliferation analyses indicated that the prepared nanocomposites did not exhibit non-cytotoxicity with the human cells. In summary, the satisfactory consequences in this research work designated that the nano-GO loaded HAp/PA strut was an active implant in the treatment of cervical reconstruction. Furthermore, the osteoconductive and osseointegration properties of the prepared struts need to be analyzed and optimized for future bio-medical usages.
为了评估在颈椎重建植入治疗中，使用载纳米氧化石墨烯（nano-GO）的羟基磷灰石/聚酰胺（HAp/PA）棒进行前路颈椎切除术和融合术（ACCF）的长期生物学和临床效果。生物陶瓷羟基磷灰石（HAp）与合适的聚合物基质结合，是最接近天然生物材料形式之一，可用于硬组织和牙科再生治疗，因为其具有类似骨的化学组成结构和与人体天然骨的生物相容性。在本研究中，研究了载纳米 GO 的 HAp/PA 复合棒的开发，用于前路颈椎重建和融合术后的融合特性。对 40 名接受载纳米 GO 的 HAp/PA 棒治疗的第一或第二级 ACCF 患者进行了研究。在最终随访期间，融合率为 99%，准备好的棒的沉降值为 5%。细胞活力和增殖分析的结果表明，所制备的纳米复合材料对人细胞没有表现出非细胞毒性。总之，这项研究工作的满意结果表明，载纳米 GO 的 HAp/PA 棒是颈椎重建治疗中的一种有效植入物。此外，需要对制备的棒的骨传导和骨整合特性进行分析和优化，以用于未来的生物医学用途。
