Wang Yihan, Zhang Shutao, Nie Bin'en, Qu Xinhua, Yue Bing
Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Front Bioeng Biotechnol. 2022 May 13;10:895288. doi: 10.3389/fbioe.2022.895288. eCollection 2022.
Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant.
由于聚醚醚酮（PEEK）具有优异的机械性能且与人体皮质骨的弹性模量相似，它已成为最有前景的骨科植入材料之一。然而，由于PEEK具有生物惰性，植入相关感染（IAIs）仍然是一个具有挑战性的问题。为了制备抗菌生物功能表面，人们对PEEK的改性进行了广泛研究。本文综述了使PEEK具有抗菌生物功能的改性策略。我们将首先回顾不同的方法，如表面涂层改性和抗菌剂的控释。此外，还讨论了共混改性和3D打印技术。最后，我们比较了不同方法之间的效果。我们旨在深入了解抗菌改性并优化PEEK骨科植入物的设计。
