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PEEK/纳米硅酸镁复合的具有磺酸基团的大-微孔表面和微-纳结构表现出抗菌活性和诱导细胞反应。

Macro-Microporous Surface with Sulfonic Acid Groups and Micro-Nano Structures of PEEK/Nano Magnesium Silicate Composite Exhibiting Antibacterial Activity and Inducing Cell Responses.

机构信息

Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China.

Department of Oncology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Apr 9;15:2403-2417. doi: 10.2147/IJN.S238287. eCollection 2020.

DOI:10.2147/IJN.S238287
PMID:32308391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7155204/
Abstract

PURPOSE

To improve the surface bio-properties of polyetheretherketone (PEEK)/nano magnesium silicate (n-MS) composite (PC).

MATERIALS AND METHODS

The surface of PC was firstly treated by particle impact (PCP) and subsequently modified by concentrated sulfuric acid (PCPS).

RESULTS

PCPS surface exhibited not only macropores with sizes of about 150 μm (fabricated by particle impact) but also micropores with sizes of about 2 μm (created by sulfonation of PEEK) on the macroporous walls, and sulfonic acid (-SOH) groups were introduced on PCPS surface. In addition, many n-MS nanoparticles were exposed on the microporous walls, which formed micro-nano structures. Moreover, the surface roughness and hydrophilicity of PCPS were obviously enhanced as compared with PC and PCP. Moreover, the apatite mineralization of PCPS in simulated body fluid (SBF) was obviously improved as compared with PC. Furthermore, compared with PC and PCP, PCPS exhibited antibacterial performances due to the presence of -SOH groups. In addition, the responses (eg, adhesion and proliferation as well as differentiation) of bone marrow mesenchymal stem cell of rat to PCPS were significantly promoted as compared with PC and PCP.

CONCLUSION

PCPS with macro-microporous surface containing -SOH groups and micro-nano structures exhibited antibacterial activity and induced cell responses, which might possess large potential for bone substitute and repair.

摘要

目的

改善聚醚醚酮（PEEK）/纳米硅酸镁（n-MS）复合材料（PC）的表面生物性能。

材料与方法

首先通过颗粒冲击（PCP）对 PC 表面进行处理，然后用浓硫酸（PCPS）进行改性。

结果

PCPS 表面不仅在大孔壁上呈现出约 150μm 的大孔（由颗粒冲击产生），而且还呈现出约 2μm 的微孔（由 PEEK 的磺化作用产生），并且在 PCPS 表面引入了磺酸基（-SOH）。此外，许多 n-MS 纳米颗粒暴露在微孔壁上，形成了微纳结构。此外，与 PC 和 PCP 相比，PCPS 的表面粗糙度和亲水性明显提高。此外，与 PC 相比，PCPS 在模拟体液（SBF）中的磷灰石矿化明显提高。此外，与 PC 和 PCP 相比，由于存在-SOH 基团，PCPS 表现出抗菌性能。此外，大鼠骨髓间充质干细胞对 PCPS 的反应（如粘附、增殖和分化）明显优于 PC 和 PCP。

结论

具有含-SOH 基团的宏观-微孔表面和微纳结构的 PCPS 具有抗菌活性和诱导细胞反应的能力，可能在骨替代和修复方面具有巨大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/8539ed46224a/IJN-15-2403-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/0124193a331e/IJN-15-2403-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/b4778ab4abb4/IJN-15-2403-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/7ed6e8ca37ba/IJN-15-2403-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/b955fcb7fd3b/IJN-15-2403-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/c9d0f6c962df/IJN-15-2403-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/f327c061a82e/IJN-15-2403-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/9095436bdc3c/IJN-15-2403-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/2c5a7097c383/IJN-15-2403-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/8539ed46224a/IJN-15-2403-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/0124193a331e/IJN-15-2403-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/b4778ab4abb4/IJN-15-2403-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/7ed6e8ca37ba/IJN-15-2403-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/b955fcb7fd3b/IJN-15-2403-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/c9d0f6c962df/IJN-15-2403-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/f327c061a82e/IJN-15-2403-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/9095436bdc3c/IJN-15-2403-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/2c5a7097c383/IJN-15-2403-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/7155204/8539ed46224a/IJN-15-2403-g0009.jpg

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