含免疫球蛋白A的人杂交免疫球蛋白M
Human hybrid immunoglobulin M containing immunoglobulin A.
作者信息
Shinmoto H, Murakami H, Dosako S, Yamada K, Omura H
机构信息
Technical Research Institute, Snow Brand Milk Products Co., Ltd., Kawagoe, Japan.
出版信息
In Vitro Cell Dev Biol. 1988 Jun;24(6):505-10. doi: 10.1007/BF02629083.
Some hybridoma clones made by fusion of a human lymphoblastoid cell line, HO323 with human B lymphocytes, secreted not only IgA but also IgM-like immunoglobulin molecules. The IgM-like immunoglobulin had a molecular size of 900 K which corresponded to that of IgM. Immunochemical analyses revealed that the IgM-like immunoglobulin contained two monomeric IgA and three monomeric IgM molecules. In the IgA moieties, half of original light chains were replaced with kappa chains derived from the IgM, and vice versa.
一些通过将人淋巴母细胞系HO323与人B淋巴细胞融合制备的杂交瘤克隆，不仅分泌IgA，还分泌IgM样免疫球蛋白分子。该IgM样免疫球蛋白的分子大小为900K，与IgM的大小相当。免疫化学分析表明，该IgM样免疫球蛋白包含两个单体IgA和三个单体IgM分子。在IgA部分，一半的原始轻链被源自IgM的κ链取代，反之亦然。
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