• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum.VκIIIb轻链亚亚组：在正常人血清中与μ重链的限制性关联。
Immunology. 1985 Feb;54(2):207-13.
2
Isoelectric focusing characterization of IgM-VKiiib immunoglobulin light chains and their association with anti-IgG autoantibodies in essential mixed cryoglobulinaemia, Sjögren's syndrome and rheumatoid arthritis.原发性混合性冷球蛋白血症、干燥综合征和类风湿关节炎中IgM-VKiiib免疫球蛋白轻链的等电聚焦特性及其与抗IgG自身抗体的关联
Immunology. 1987 Dec;62(4):529-36.
3
An immunochemical evaluation for the identification and typing of monoclonal proteins.用于单克隆蛋白鉴定和分型的免疫化学评估。
Ann Clin Biochem. 1990 Jul;27 ( Pt 4):327-34. doi: 10.1177/000456329002700408.
4
Use of immunoglobulin heavy- and light-chain measurements compared with existing techniques as a means of typing monoclonal immunoglobulins.与现有技术相比，使用免疫球蛋白重链和轻链测量作为单克隆免疫球蛋白分型的一种手段。
Clin Chem. 1987 Oct;33(10):1771-3.
5
Distribution and association of heavy and light chain variable region subgroups among human IgA immunoglobulins.人IgA免疫球蛋白中重链和轻链可变区亚组的分布及关联
J Immunol. 1975 Feb;114(2 Pt 1):678-81.
6
The V kappa IIIb light chain sub-subgroup. II. Isotype expression in acquired hypogammaglobulinaemia and as a function of age.VκIIIb轻链亚亚组。II. 获得性低丙种球蛋白血症中的同种型表达及其与年龄的关系。
Immunology. 1986 Feb;57(2):325-7.
7
Heavy and light chain variable region subgroups: antigenic analysis among human monoclonal immunoglobulins.重链和轻链可变区亚组：人单克隆免疫球蛋白的抗原分析
Ann Immunol (Paris). 1976 Jun-Jul;127(3-4):303-15.
8
Medical and technical usefulness of measurement of kappa and lambda immunoglobulin light chains in serum with an M-component.血清中κ和λ免疫球蛋白轻链与M蛋白成分检测的医学及技术应用价值
J Clin Chem Clin Biochem. 1989 Aug;27(8):519-23.
9
Light-chain ratios of immunoglobulins G, A, and M determined by enzyme immunoassay.通过酶免疫测定法测定免疫球蛋白G、A和M的轻链比率。
Clin Chem. 1990 Mar;36(3):501-2.
10
Biased utilization of immunoglobulin variable region heavy- and light-chain genes by the malignant CD5- B lymphocytes from patients with Burkitt's lymphoma.伯基特淋巴瘤患者恶性CD5 - B淋巴细胞对免疫球蛋白可变区重链和轻链基因的偏向性利用。
Int J Cancer. 1994 Jul 15;58(2):226-32. doi: 10.1002/ijc.2910580214.

引用本文的文献

1
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.自身抗体相关的κ轻链可变区基因在体细胞突变很少或没有体细胞突变的慢性淋巴细胞白血病中表达。对病因学和免疫治疗的意义。
J Exp Med. 1988 Mar 1;167(3):840-52. doi: 10.1084/jem.167.3.840.
2
Isoelectric focusing characterization of IgM-VKiiib immunoglobulin light chains and their association with anti-IgG autoantibodies in essential mixed cryoglobulinaemia, Sjögren's syndrome and rheumatoid arthritis.原发性混合性冷球蛋白血症、干燥综合征和类风湿关节炎中IgM-VKiiib免疫球蛋白轻链的等电聚焦特性及其与抗IgG自身抗体的关联
Immunology. 1987 Dec;62(4):529-36.
3
Human rheumatoid factor crossidiotypes. II. Primary structure-dependent crossreactive idiotype, PSL2-CRI, present on Wa monoclonal rheumatoid factors is present on Bla and other IgM kappa monoclonal autoantibodies.人类风湿因子交叉独特型。II. 存在于Wa单克隆类风湿因子上的依赖一级结构的交叉反应独特型PSL2-CRI，也存在于Bla和其他IgM κ单克隆自身抗体上。
J Exp Med. 1987 Jan 1;165(1):263-7. doi: 10.1084/jem.165.1.263.
4
The V kappa IIIb light chain sub-subgroup. II. Isotype expression in acquired hypogammaglobulinaemia and as a function of age.VκIIIb轻链亚亚组。II. 获得性低丙种球蛋白血症中的同种型表达及其与年龄的关系。
Immunology. 1986 Feb;57(2):325-7.
5
Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.一种人类抗巨细胞病毒抗体克隆重链和轻链可变区的完整蛋白质序列，与Wa独特型家族的人类单克隆类风湿因子显示出惊人的相似性。
J Clin Invest. 1988 May;81(5):1511-8. doi: 10.1172/JCI113483.
6
Immunogenic and antigenic epitopes of immunoglobulins. XVIII. Subpopulations of human lambda chains defined with a panel of monoclonal antibodies.免疫球蛋白的免疫原性和抗原表位。十八。用一组单克隆抗体界定的人λ链亚群。
Immunology. 1986 Nov;59(3):467-71.

本文引用的文献

1
Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies.半抗原特异性单克隆抗体重链和轻链的限制性重缔合。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5807-11. doi: 10.1073/pnas.78.9.5807.
2
Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies.κIIIb轻链与单克隆人IgMκ自身抗体的优先缔合。
J Immunol. 1983 Sep;131(3):1322-5.
3
Immunoglobulin VH determinants defined by monoclonal antibodies.由单克隆抗体定义的免疫球蛋白VH决定簇。
J Exp Med. 1982 Oct 1;156(4):1010-24. doi: 10.1084/jem.156.4.1010.
4
Bence Jones proteins and light chains of immunoglobulins. IV. Immunochemical differentiation among proteins within each of the three established kappa-chain classes.本斯·琼斯蛋白与免疫球蛋白轻链。IV. 三种已确定的κ链类别中每种类别内蛋白质的免疫化学鉴别
J Immunol. 1971 Jan;106(1):120-7.
5
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal).人IgM冷凝集素的轻链序列（可变区亚组氨基酸序列-κ轻链- N端）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):40-3. doi: 10.1073/pnas.69.1.40.
6
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities.显示交叉独特型特异性的抗γ球蛋白轻链中的相似性。
J Exp Med. 1974 Jan 1;139(1):128-36. doi: 10.1084/jem.139.1.128.
7
Specificity of recombination of H and L chains from human gamma-G-myeloma proteins.人γ-G-骨髓瘤蛋白重链和轻链重组的特异性
J Exp Med. 1965 Sep 1;122(3):619-32. doi: 10.1084/jem.122.3.619.
8
Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.酶联免疫吸附测定法，即酶标法。3. 通过在包被抗原的试管中用酶标记抗免疫球蛋白来定量特异性抗体。
J Immunol. 1972 Jul;109(1):129-35.
9
Kappa chain (V kappa III) subgroup-related activity in an idiotypic anti-cold agglutinin serum.独特型抗冷凝集素血清中κ链（VκIII）亚群相关活性
Scand J Immunol. 1976;5(6-7):629-36. doi: 10.1111/j.1365-3083.1976.tb03012.x.
10
Specific interaction between VH and VL regions of human monoclonal immunoglobulins.
J Mol Biol. 1976 Apr 15;102(3):657-78. doi: 10.1016/0022-2836(76)90340-5.

VκIIIb轻链亚亚组：在正常人血清中与μ重链的限制性关联。

The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum.

作者信息

Moynihan J A, Looney R J, Abraham G N

出版信息

Immunology. 1985 Feb;54(2):207-13.

PMID:3917972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453503/
Abstract

The VKIII human kappa light chain subgroup has been serologically and structurally divided into two sub-subgroups, VKIIIa and VKIIIb. VKIIIb has been shown by others to be strikingly prevalent in IgM autoantibodies, but no studies have been performed to determine heavy chain isotype association with VKIIIb light chain in normal human serum. The VKIIIb sub-subgroup was shown here to be associated with mu heavy chain in normal human serum, but was not detected in association with gamma or alpha heavy chain. Approximately 25 +/- 15% of IgM-kappa was determined to be VKIIIb. Both intact IgG and purified light chains from pooled IgG did not bind monoclonal anti-VKIIIb, indicating that the determinants recognized by anti-VKIIIb are not merely masked in intact IgG. These results are the first report of a light chain sub-subgroup showing preferential association with a heavy chain isotype.

摘要

人κ轻链III亚组已通过血清学和结构学分为两个次亚组，即VKIIIa和VKIIIb。其他人已表明VKIIIb在IgM自身抗体中显著普遍存在，但尚未进行研究以确定正常人血清中重链同种型与VKIIIb轻链的关联。本文显示，正常人血清中VKIIIb次亚组与μ重链相关，但未检测到与γ或α重链相关。约25±15%的IgM-κ被确定为VKIIIb。完整的IgG和来自混合IgG的纯化轻链均不与单克隆抗VKIIIb结合，表明抗VKIIIb识别的决定簇在完整IgG中并非仅仅被掩盖。这些结果是关于轻链次亚组与重链同种型显示优先关联的首次报道。