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[铜绿假单胞菌:尿路感染中的致病性与抗菌耐药性]

[Pseudomonas aeruginosa: Pathogenicity and antimicrobial resistance in urinary tract infection].

作者信息

Paz-Zarza Victor Manuel, Mangwani-Mordani Simran, Martínez-Maldonado Alejandra, Álvarez-Hernández Diego, Solano-Gálvez Sandra Georgina, Vázquez-López Rosalino

机构信息

Centro de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Estado de México, México.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

出版信息

Rev Chilena Infectol. 2019 Apr;36(2):180-189. doi: 10.4067/S0716-10182019000200180.

Abstract

Among the most frequent nosocomial infections associated with polyresistant bacteria and with a worse prognosis, are those produced by Pseudomonas aeruginosa. This bacterium has a high capacity to adapt to adverse conditions such as pH and osmolarity of urine. Pseudomonas aeruginosa is one of the main pathogens involved in nosocomial infections and immunosuppressed patients. This bacterium is considered an opportunistic infectious agent that has diverse mechanisms of pathogenicity, as well as resistance to antimicrobials, which contributes to the difficulty in the treatment of these infections. In the present bibliographic review, the taxonomy, pathogenicity mechanisms and resistance genes of P. aeruginosa are analyzed. Likewise, the micro-environmental factors of the urinary infection produced by this bacterium are approached, making an approach to the understanding of the pathophysiological bases of this infection.

摘要

在与多重耐药菌相关且预后较差的最常见医院感染中,由铜绿假单胞菌引起的感染位列其中。这种细菌具有很强的适应不利条件的能力,比如尿液的酸碱度和渗透压。铜绿假单胞菌是医院感染和免疫抑制患者中主要的病原体之一。这种细菌被认为是一种机会性感染因子,具有多种致病机制以及对抗菌药物的耐药性,这导致了这些感染治疗上的困难。在本次文献综述中,分析了铜绿假单胞菌的分类学、致病机制和耐药基因。同样,探讨了由这种细菌引起的泌尿系统感染的微环境因素,以便对这种感染的病理生理基础有更深入的了解。

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