Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Microbiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Int J Mol Sci. 2021 Nov 29;22(23):12892. doi: 10.3390/ijms222312892.
In recent years, the effectiveness of antimicrobials in the treatment of infections has gradually decreased. This pathogen can be observed in several clinical cases, such as pneumonia, urinary tract infections, sepsis, in immunocompromised hosts, such as neutropenic cancer, burns, and AIDS patients. Furthermore, causes diseases in both livestock and pets. The highly flexible and versatile genome of allows it to have a high rate of pathogenicity. The numerous secreted virulence factors, resulting from its numerous secretion systems, the multi-resistance to different classes of antibiotics, and the ability to produce biofilms are pathogenicity factors that cause numerous problems in the fight against infections and that must be better understood for an effective treatment. Infections by represent, therefore, a major health problem and, as resistance genes can be disseminated between the microbiotas associated with humans, animals, and the environment, this issue needs be addressed on the basis of an One Health approach. This review intends to bring together and describe in detail the molecular and metabolic pathways in 's pathogenesis, to contribute for the development of a more targeted therapy against this pathogen.
近年来，抗生素在治疗感染方面的效果逐渐减弱。这种病原体在多种临床病例中都能观察到，如肺炎、尿路感染、败血症，在免疫功能低下的宿主中，如中性粒细胞减少症癌症、烧伤和艾滋病患者中也能观察到。此外，它还会导致家畜和宠物患病。的高度灵活和多功能基因组使其具有高致病性。其众多分泌的毒力因子，源于其众多分泌系统，对不同类别的抗生素的多耐药性，以及产生生物膜的能力，这些都是导致感染治疗中出现诸多问题的致病性因素，需要更好地理解以实现有效的治疗。因此，感染代表着一个主要的健康问题，而且由于耐药基因可以在与人类、动物和环境相关的微生物群之间传播，因此需要基于一种“同一健康”方法来解决这个问题。本综述旨在综合并详细描述在‘的发病机制中的分子和代谢途径，为针对这种病原体的更有针对性的治疗方法的发展做出贡献。
