PVA/SA/TiO-CUR 贴片在促进伤口愈合中的应用：体外和体内分析。
PVA/SA/TiO-CUR patch for enhanced wound healing application: In vitro and in vivo analysis.
机构信息
Department of Nanotechnology, SRM Institute of Science and Technology, Tamil Nadu, India.
Department of Physics, SRM Institute of Science and Technology, Tamil Nadu, India.
出版信息
Int J Biol Macromol. 2019 Oct 1;138:704-717. doi: 10.1016/j.ijbiomac.2019.07.125. Epub 2019 Jul 22.
Wound healing is a complex multistep process. Wound healing materials should have good antibacterial activity against wound infection causing microbes. Curcumin has effective antimicrobial activity, anti-inflammatory and antioxidant property. Titanium dioxide (TiO) is a biocompatible, nontoxic material used for many biomedical applications. The Usage of curcumin tagged TiO nanoparticles for wound healing activity is promising due to the properties of both curcumin and TiO. We have synthesized curcumin tagged TiO nanoparticles. The synthesized materials are characterized with XRD, FTIR and TEM. TiO-Cur nanocomposite was incorporated into poly vinyl alcohol (PVA) and sodium alginate (SA) patch. The PVA/SA/TiO-Cur patch was prepared by gel casting method. Antibacterial efficiency of PVA/SA/TiO-Cur patch was analyzed. Further, in vivo studies conducted on Wister rats confirmed the enhanced wound healing property of the PVA/SA/TiO-Cur patch. Our results suggest that this could be an ideal biomaterial for wound dressing applications.
创伤愈合是一个复杂的多步骤过程。创伤愈合材料应该对引起伤口感染的微生物具有良好的抗菌活性。姜黄素具有有效的抗菌活性、抗炎和抗氧化特性。二氧化钛（TiO）是一种生物相容性、无毒的材料，用于许多生物医学应用。由于姜黄素和 TiO 的特性，使用标记有姜黄素的 TiO 纳米粒子进行创伤愈合活性具有很大的应用前景。我们已经合成了标记有姜黄素的 TiO 纳米粒子。合成的材料用 XRD、FTIR 和 TEM 进行了表征。TiO-Cur 纳米复合材料被掺入到聚乙烯醇（PVA）和海藻酸钠（SA）贴片。PVA/SA/TiO-Cur 贴片是通过凝胶浇铸法制备的。分析了 PVA/SA/TiO-Cur 贴片的抗菌效率。此外，在 Wister 大鼠上进行的体内研究证实了 PVA/SA/TiO-Cur 贴片增强的创伤愈合性能。我们的结果表明，这可能是一种理想的用于伤口敷料的生物材料。
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