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二氧化钛纳米颗粒：伤口愈合应用的一个有前景的候选材料。

Titanium dioxide nanoparticles: a promising candidate for wound healing applications.

作者信息

Nosrati Hamed, Heydari Morteza

机构信息

Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.

Research Group of Immune Cell Communication, Department of Immune Medicine, Universitätsklinikum Regensburg | UKR, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

出版信息

Burns Trauma. 2025 Jan 3;13:tkae069. doi: 10.1093/burnst/tkae069. eCollection 2025.

DOI:10.1093/burnst/tkae069
PMID:39759542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11697110/
Abstract

Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short in fully addressing the complexities of skin wound healing. Recent advancements in tissue engineering have introduced innovative approaches, particularly through the use of nanobiomaterials, to enhance the healing process. In this context, titanium dioxide nanoparticles (TiO NPs) have garnered attention due to their excellent biological properties, including antioxidant, anti-inflammatory, and antimicrobial properties. Furthermore, these nanoparticles can be modified to enhance their therapeutic benefits. Scaffolds and dressings containing TiO NPs have demonstrated promising outcomes in accelerating wound healing and enhancing tissue regeneration. This review paper covers the wound healing process, the biological properties of TiO NPs that make them suitable for promoting wound healing, methods for synthesizing TiO NPs, the use of scaffolds and dressings containing TiO NPs in wound healing, the application of modified TiO NPs in wound healing, and the potential toxicity of TiO NPs.

摘要

有效的伤口管理和治疗在临床实践中至关重要，但现有的策略往往不足以全面应对皮肤伤口愈合的复杂性。组织工程学的最新进展引入了创新方法，特别是通过使用纳米生物材料来促进愈合过程。在此背景下，二氧化钛纳米颗粒（TiO NPs）因其优异的生物学特性，包括抗氧化、抗炎和抗菌特性而受到关注。此外，这些纳米颗粒可以进行修饰以增强其治疗效果。含有TiO NPs的支架和敷料在加速伤口愈合和促进组织再生方面已显示出有前景的结果。这篇综述论文涵盖了伤口愈合过程、使TiO NPs适合促进伤口愈合的生物学特性、TiO NPs的合成方法、含有TiO NPs的支架和敷料在伤口愈合中的应用、修饰后的TiO NPs在伤口愈合中的应用以及TiO NPs的潜在毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/ffdb48e9561f/tkae069f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/7f30fa0877d5/tkae069f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/42cf1ef5a0f2/tkae069f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/43d79ae9acb0/tkae069f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/9c3e5dbc39df/tkae069f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/5e76d26b097b/tkae069f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/8125dd5b6320/tkae069f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/e7bdc5fefd30/tkae069f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/ffdb48e9561f/tkae069f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/7f30fa0877d5/tkae069f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/42cf1ef5a0f2/tkae069f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/43d79ae9acb0/tkae069f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/9c3e5dbc39df/tkae069f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/5e76d26b097b/tkae069f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/8125dd5b6320/tkae069f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/e7bdc5fefd30/tkae069f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9853/11697110/ffdb48e9561f/tkae069f8.jpg

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