Hamilton Adelle E, Gilbert Ryan J
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
Bioengineering (Basel). 2023 Feb 16;10(2):262. doi: 10.3390/bioengineering10020262.
Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin's effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin's principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly to injury sites, researchers have harnessed the beneficial natural properties of curcumin while providing scaffolding to support tissue regeneration. This review will provide an in-depth overview of the literature that utilizes biomaterial delivery of curcumin for tissue regeneration in injury and disease models.
姜黄素是一种从姜黄中提取的具有生物活性的酚类物质，是一种抗氧化、抗炎和抗菌分子。尽管姜黄素以其天然形式呈现出有益效果，但其高度疏水，导致水溶性差，进而生物利用度低。生物利用度的缺乏限制了姜黄素作为治疗手段的有效性，并限制了其在临床应用中的使用。此外，为了获得有益的、临床相关的结果，全身给药需要高剂量的姜黄素。许多研究人员利用生物材料载体，包括电纺纤维、纳米颗粒、水凝胶和复合支架，来克服姜黄素生物利用度低这一主要治疗局限性。通过使用生物材料将姜黄素直接递送至损伤部位，研究人员在利用姜黄素有益天然特性的同时，提供了支持组织再生的支架。本综述将深入概述利用生物材料递送姜黄素用于损伤和疾病模型中组织再生的文献。
