Al-Naymi Hanan Adnan Shaker, Al-Musawi Mastafa H, Mirhaj Marjan, Valizadeh Hamideh, Momeni Arefeh, Danesh Pajooh Amir Mohammad, Shahriari-Khalaji Mina, Sharifianjazi Fariborz, Tavamaishvili Ketevan, Kazemi Nafise, Salehi Saeideh, Arefpour Ahmadreza, Tavakoli Mohamadreza
Department of Chemistry, College of Education for Pure Science/Ibn Al-Haitham, University of Baghdad, Baghdad, Iraq.
Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Heliyon. 2024 Sep 26;10(19):e38497. doi: 10.1016/j.heliyon.2024.e38497. eCollection 2024 Oct 15.
Wound healing is a sophisticated process for which various treatment methods have been developed. Bioceramics with the ability to release inorganic ions in biological environments play a crucial role in cellular metabolism and exhibit bactericidal activity, contributing to numerous physiological processes. Their multifaceted roles in biological systems highlight their significance. The release of different metallic ions from bioceramics enables the repair of both hard and soft tissues. These ions may be effective in cell motility, proliferation, differentiation, adhesion, angiogenesis, and antibiosis. Unlike conventional medications, the bioactivity and antibacterial properties of bioceramics are typically not associated with side effects or bacterial resistance. Bioceramics are commonly recognized for their capcity to facilitate the healing of hard tissues due to their exceptional mechanical properties. In this review, we first explore wound treatment and its prevalent methods, and subsequently, we discuss the application of three primary categories of bioceramics-oxide ceramics, silicate-based ceramics, and calcium-phosphate ceramics-in the context of wound treatment. This review introduces bioceramics as a cost-effective and efficient alternative for wound repair. Our aim is to inspire researchers to incorporate bioceramics with other biomaterials to achieve enhanced, economical, expedited, and safer wound healing.
伤口愈合是一个复杂的过程，针对此已开发出多种治疗方法。能够在生物环境中释放无机离子的生物陶瓷在细胞代谢中起着关键作用，并具有杀菌活性，有助于众多生理过程。它们在生物系统中的多方面作用凸显了其重要性。生物陶瓷释放不同的金属离子能够修复硬组织和软组织。这些离子在细胞运动、增殖、分化、黏附、血管生成和抗菌方面可能具有有效性。与传统药物不同，生物陶瓷的生物活性和抗菌特性通常不会产生副作用或细菌耐药性。生物陶瓷因其卓越的机械性能而通常被认为具有促进硬组织愈合的能力。在本综述中，我们首先探讨伤口治疗及其常见方法，随后，我们在伤口治疗的背景下讨论三类主要生物陶瓷——氧化物陶瓷、硅酸盐基陶瓷和磷酸钙陶瓷——的应用。本综述将生物陶瓷作为一种经济高效的伤口修复替代品进行介绍。我们的目的是激励研究人员将生物陶瓷与其他生物材料结合，以实现更高效、经济、快速且安全的伤口愈合。
