Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Nov;234(11):19320-19330. doi: 10.1002/jcp.28626. Epub 2019 Apr 4.
Turmeric extracts contain three primary compounds, which are commonly referred to as curcuminoids. They are curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin. While curcumin has been the most extensively studied of the curcuminoids, it suffers from low overall oral bioavailability due to extremely low absorption as a result of low water solubility and instability at acidic pH, as well as rapid metabolism and clearance from the body. However, DMC, which lacks the methoxy group on the benzene ring of the parent structure, has much greater chemical stability at physiological pH and has been recently reported to exhibit antitumor properties. However, the treatment of noncancerous diseases with DMC has not been comprehensively reviewed. Therefore, here we evaluate published scientific literature on the therapeutic properties of DMC. The beneficial pharmacological actions of DMC include anti-inflammatory, neuroprotective, antihypertensive, antimalarial, antimicrobial, antifungal, and vasodilatory properties. In addition, DMC's ability to ameliorate the effects of free radicals and an environment characterized by oxidative stress caused by the accumulation of advanced glycation end-products associated with diabetic nephropathy, as well as DMC's capacity to inhibit the migration and proliferation of vascular smooth muscle cells following balloon angioplasty are also addressed. This review collates the available literature regarding the therapeutic possibilities of DMC in noncancerous conditions.
姜黄提取物含有三种主要化合物，通常被称为姜黄素类化合物。它们是姜黄素、脱甲氧基姜黄素（DMC）和双脱甲氧基姜黄素。虽然姜黄素是姜黄素类化合物中研究最多的一种，但由于其极低的水溶性和在酸性 pH 值下的不稳定性，以及在体内的快速代谢和清除，导致其整体口服生物利用度极低，因此受到了极大的限制。然而，DMC 缺乏母体结构苯环上的甲氧基，在生理 pH 值下具有更高的化学稳定性，并且最近有报道称其具有抗肿瘤特性。然而，DMC 治疗非癌症疾病的情况尚未得到全面审查。因此，在这里我们评估了关于 DMC 治疗特性的已发表科学文献。DMC 的有益药理作用包括抗炎、神经保护、降压、抗疟、抗菌、抗真菌和血管舒张作用。此外，DMC 还能改善由糖尿病肾病相关的晚期糖基化终产物积累引起的自由基和氧化应激环境的影响，以及抑制球囊血管成形术后血管平滑肌细胞的迁移和增殖。本综述汇集了关于 DMC 在非癌症情况下的治疗可能性的现有文献。
