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Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation.

作者信息

Parenteau T Richard, Celli Anna, Zhang Jiechen, Gonzalez Jeanmarie, Meyer Jason M, Abegaze Brook, Piper Merisa L, Elias Peter M, Abuabara Katrina, Grunfeld Carl, Man Mao-Qiang, Scharschmidt Tiffany C, Mauro Theodora M

机构信息

Division of Geriatrics, University of California, San Francisco, San Francisco, California, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, California, USA.

Dermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.

出版信息

J Invest Dermatol. 2025 Jun;145(6):1512-1516.e4. doi: 10.1016/j.jid.2024.12.010. Epub 2024 Dec 31.

DOI:10.1016/j.jid.2024.12.010
PMID:39746572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12103278/
Abstract
摘要

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本文引用的文献

1
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging.角质层水合作用与老年人的某些血清细胞因子水平呈负相关，这可能是导致炎症衰老的原因之一。
Immun Ageing. 2023 Feb 7;20(1):7. doi: 10.1186/s12979-023-00331-1.
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Aging of the skin barrier.皮肤屏障的老化。
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Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study.局部应用保湿剂可降低慢性老年人群中循环促炎细胞因子水平：一项初步临床研究。
J Eur Acad Dermatol Venereol. 2019 Nov;33(11):2197-2201. doi: 10.1111/jdv.15540. Epub 2019 Mar 27.
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Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells.经皮致敏于屋尘螨变应原需要干扰素调节因子 4 依赖性皮肤树突状细胞。
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Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines.表皮功能障碍导致血清炎症细胞因子水平随年龄增长而升高。
J Invest Dermatol. 2017 Jun;137(6):1277-1285. doi: 10.1016/j.jid.2017.01.007. Epub 2017 Jan 20.
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Topical hesperidin enhances epidermal function in an aged murine model.局部应用橙皮苷可增强老年小鼠模型的表皮功能。
J Invest Dermatol. 2015 Apr;135(4):1184-1187. doi: 10.1038/jid.2014.486. Epub 2014 Nov 17.
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Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family.老年表皮细胞因子调节的改变：对渗透屏障稳态和炎症的影响。I.白细胞介素-1基因家族。
Exp Dermatol. 2002 Jun;11(3):209-16. doi: 10.1034/j.1600-0625.2002.110303.x.
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Integrity and permeability barrier function of photoaged human epidermis.
Arch Dermatol. 1997 Mar;133(3):395-6.
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Superficial hemorrhagic fissures of the skin.
Arch Dermatol. 1970 Apr;101(4):442-51.
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Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content.皮肤老化。对经表皮水分流失、角质层水合作用、皮肤表面pH值和皮脂含量的影响。
Arch Dermatol. 1991 Dec;127(12):1806-9. doi: 10.1001/archderm.127.12.1806.