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HY•1的发现：一种具有抗衰老和皮肤修复特性的新型多功能护肤成分。

Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties.

作者信息

Duan Xilei, Lu Zhong

机构信息

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

出版信息

J Cosmet Dermatol. 2025 May;24(5):e70135. doi: 10.1111/jocd.70135.

DOI:10.1111/jocd.70135
PMID:40367094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12077748/
Abstract

OBJECTIVES

Skin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage. The objective of this work is to demonstrate HY-1, a three-peptide conjugate shown to have antioxidation, anti-inflammatory efficacy in vitro, and clinical benefits in anti-wrinkle, is an efficacious ingredient for skin aging.

METHOD

The antioxidation efficacy was studied on the ROS test, and the antiaging efficacy was studied on ex vivo human skin. In the clinical study, 49 subjects aged between 26 and 54 with wrinkle concerns were recruited and instructed to apply the investigational cream containing HY-1 for 28 days. Wrinkle attributes were assessed by dermatologists. Instrumental measurements were also conducted.

RESULTS

In vitro studies of HY-1 on HSF and HaCaT cells demonstrated significant efficacy in scavenging reactive oxygen species (ROS) and exerting anti-inflammatory effects, as evidenced by decreased ROS production and reduced expression of interleukin-6 (IL-6). Clinical study demonstrated significant improvement in skin condition, including firmness, nourishment, and anti-wrinkle.

CONCLUSION

HY-1 is a novel skincare ingredient, addressing the visible manifestations of aging and photodamage. Its multifaceted capabilities, encompassing antioxidant properties, enhancement of skin firmness, nourishment, and anti-wrinkle effects, represent a pioneering approach with the potential to provide a skincare alternative.

摘要

目的

皮肤老化受内在和外在因素影响，包括紫外线辐射引起的光老化，导致活性氧生成和皮肤损伤。本研究的目的是证明HY - 1，一种三肽共轭物，在体外具有抗氧化、抗炎功效，在抗皱方面具有临床益处，是一种治疗皮肤老化的有效成分。

方法

通过活性氧测试研究其抗氧化功效，在离体人皮肤上研究其抗老化功效。在临床研究中，招募了49名年龄在26至54岁之间、有皱纹问题的受试者，并指导他们使用含有HY - 1的试验性乳膏28天。由皮肤科医生评估皱纹特征。还进行了仪器测量。

结果

HY - 1对人皮肤成纤维细胞（HSF）和人角质形成细胞（HaCaT）的体外研究表明，它在清除活性氧（ROS）和发挥抗炎作用方面具有显著功效，活性氧生成减少和白细胞介素 - 6（IL - 6）表达降低证明了这一点。临床研究表明皮肤状况有显著改善，包括紧致度、营养状况和抗皱效果。

结论

HY - 1是一种新型护肤成分，可解决衰老和光损伤的明显表现。其多方面的能力，包括抗氧化特性、增强皮肤紧致度、营养状况和抗皱效果，代表了一种开创性的方法，有可能提供一种护肤替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/b4ee8818eaa1/JOCD-24-e70135-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/8ae541c258f9/JOCD-24-e70135-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/e262dad42ba6/JOCD-24-e70135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/18901fe726d6/JOCD-24-e70135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/db4c310d3012/JOCD-24-e70135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/87448b0fa903/JOCD-24-e70135-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/b4ee8818eaa1/JOCD-24-e70135-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/8ae541c258f9/JOCD-24-e70135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/b00363016073/JOCD-24-e70135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/474e45eb6701/JOCD-24-e70135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/be40d35decdb/JOCD-24-e70135-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/33bc70bfae54/JOCD-24-e70135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/9aef999ec0e2/JOCD-24-e70135-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/e262dad42ba6/JOCD-24-e70135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/18901fe726d6/JOCD-24-e70135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/db4c310d3012/JOCD-24-e70135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/87448b0fa903/JOCD-24-e70135-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/f1f7c4b39e9a/JOCD-24-e70135-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/033900e737ab/JOCD-24-e70135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12077748/b4ee8818eaa1/JOCD-24-e70135-g011.jpg

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