Garnick M B, Skarin A T, Steele G D
J Urol. 1979 Aug;122(2):265-6. doi: 10.1016/s0022-5347(17)56360-0.
A case of extensive metastatic epidermoid carcinoma of the penis is reported. Disseminated disease developed after penectomy and lymphadenectomy and it continued to progress while the patient received radiation therapy. Chemotherapy with high dose methotrexate followed by citrovorum factor rescue was instituted. After completion of 10 weekly cycles of treatment there was biopsy-proved complete regression of all lesions, which lasted 9 months when the patient suddenly died of pneumonia completely unrelated to the tumor or chemotherapy treatment. This chemotherapeutic approach deserves additional trial in patients with advanced stages of penile carcinoma.
报告了一例阴茎广泛转移性表皮样癌病例。阴茎切除及淋巴结切除术后出现播散性疾病，患者接受放射治疗时病情仍持续进展。遂采用大剂量甲氨蝶呤化疗并随后用亚叶酸钙解救。在完成10个每周疗程的治疗后，活检证明所有病灶完全消退，这种情况持续了9个月，之后患者突然死于与肿瘤或化疗治疗完全无关的肺炎。这种化疗方法值得在晚期阴茎癌患者中进行进一步试验。
