甲氨蝶呤治疗阴茎癌
Methotrexate in the treatment of penile carcinoma.
作者信息
Sklaroff R B, Yagoda A
出版信息
Cancer. 1980 Jan 15;45(2):214-6. doi: 10.1002/1097-0142(19800115)45:2<214::aid-cncr2820450203>3.0.co;2-k.
Abstract
Eight patients with epidermoid carcinoma of the penis received methotrexate, five with high-dose methotrexate, 250--1500 mg/m2 with citrovorum rescue Q 2--4 weeks, and three with low-dose methotrexate, 0.5--3.0 mg/kg weekly. Three (38%) patients achieved a complete or partial remission which persisted for 11, 3 and 2 months, respectively. Methotrexate appears to be an active agent in the treatment of advanced penile cancer.
摘要
八例阴茎表皮样癌患者接受了甲氨蝶呤治疗，五例接受高剂量甲氨蝶呤治疗，剂量为250 - 1500mg/m²，每2 - 4周用亚叶酸钙解救一次，三例接受低剂量甲氨蝶呤治疗，剂量为0.5 - 3.0mg/kg每周。三例（38%）患者实现了完全或部分缓解，缓解分别持续了11个月、3个月和2个月。甲氨蝶呤似乎是治疗晚期阴茎癌的一种有效药物。
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