Tornyos K, Faust H
Cancer. 1978 Feb;41(2):400-2. doi: 10.1002/1097-0142(197802)41:2<400::aid-cncr2820410204>3.0.co;2-d.
Thirteen patients with metastatic squamous cell cancer of the lung were treated, in a nonrandomized study, with an oral high-dose methotrexate and citrovorum factor rescue regimen. There was some response and/or stabilization of disease for at least three months in six (46%) of 13 cases. The median survival time of the study group was double (365 vs. 180 days) that of a retrospectively matched control group. This suggests a possible therapeutic effect of this treatment program in metastatic squamous cell cancer of the lung.
在一项非随机研究中，对13例肺转移性鳞状细胞癌患者采用口服大剂量甲氨蝶呤和亚叶酸解救方案进行治疗。13例患者中有6例（46%）出现了至少三个月的疾病缓解和/或病情稳定。研究组的中位生存时间是回顾性匹配对照组的两倍（365天对180天）。这表明该治疗方案对肺转移性鳞状细胞癌可能具有治疗效果。
