Shiraishi Tomotaka, Murakami Hidetomo, Iguchi Yasuyuki
Department of Neurology, The Jikei University School of Medicine.
Brain Nerve. 2019 Aug;71(8):869-874. doi: 10.11477/mf.1416201367.
Parkinson's disease (PD) patients can present with cognitive impairment, such as deficits in attention and memory processes, visual perception, executive function and social cognition. These dysfunctions negatively affect the activities of daily living and outcome of patients. Some of the risk factors, pathological background and etiology of cognitive dysfunction in PD with dementia (PDD) have been determined. Treatments for such dysfunctions are attracting much attention. Some medications, such as donepezil, rivastigmine, and memantine, have shown to improve motor and/or cognitive functions. Cognitive impairment and motor symptoms in PD can be treated concurrently. Therefore, the correlation between motor and cognitive function should be considered when treating PD.
帕金森病（PD）患者可能会出现认知障碍，如注意力和记忆过程、视觉感知、执行功能和社会认知方面的缺陷。这些功能障碍会对患者的日常生活活动和预后产生负面影响。帕金森病痴呆（PDD）中认知功能障碍的一些风险因素、病理背景和病因已被确定。针对此类功能障碍的治疗正备受关注。一些药物，如多奈哌齐、卡巴拉汀和美金刚，已显示出可改善运动和/或认知功能。PD中的认知障碍和运动症状可以同时治疗。因此，在治疗PD时应考虑运动和认知功能之间的相关性。
