Bhaswant Maharshi, Shafie Siti Raihanah, Mathai Michael L, Mouatt Peter, Brown Lindsay
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia; School of Health and Wellbeing, University of Southern Queensland, Toowoomba, Australia.
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, Australia.
Nutrition. 2017 Sep;41:24-31. doi: 10.1016/j.nut.2016.12.009. Epub 2016 Dec 28.
Increased consumption of fruits and vegetables as functional foods leads to the reduction of signs of metabolic syndrome. The aim of this study was to measure and compare cardiovascular, liver, and metabolic parameters following chronic administration of the same dose of anthocyanins either from chokeberry (CB) or purple maize (PM) in rats with diet-induced metabolic syndrome.
Male Wistar rats were fed a maize starch (C) or high-carbohydrate, high-fat diet (H) and divided into six groups for 16 wk. The rats were fed C, C with CB or PM for the last 8 wk (CCB or CPM), H, H with CB or PM for the last 8 wk (HCB or HPM); CB and PM rats received ∼8 mg anthocyanins/kg daily. The rats were monitored for changes in blood pressure, cardiovascular and hepatic structure and function, glucose tolerance, and adipose tissue mass.
HCB and HPM rats showed reduced visceral adiposity index, total body fat mass, and systolic blood pressure; improved glucose tolerance, liver, and cardiovascular structure and function; decreased plasma triacylglycerols and total cholesterol compared with H rats. Inflammatory cell infiltration was reduced in heart and liver.
CB and PM interventions gave similar responses, suggesting that anthocyanins are the bioactive molecules in the attenuation or reversal of metabolic syndrome by prevention of inflammation-induced damage.
增加水果和蔬菜作为功能性食品的摄入量可减少代谢综合征的症状。本研究的目的是测量和比较在饮食诱导的代谢综合征大鼠中，长期给予相同剂量的来自黑果腺肋花楸（CB）或紫玉米（PM）的花青素后，心血管、肝脏和代谢参数的变化。
雄性Wistar大鼠喂食玉米淀粉（C）或高碳水化合物、高脂肪饮食（H），并分为六组，为期16周。在最后8周，大鼠分别喂食C、C加CB或PM（CCB或CPM）、H、H加CB或PM（HCB或HPM）；CB和PM组大鼠每天接受约8毫克/千克的花青素。监测大鼠血压、心血管和肝脏结构与功能、葡萄糖耐量以及脂肪组织质量的变化。
与H组大鼠相比，HCB和HPM组大鼠的内脏脂肪指数、全身脂肪量和收缩压降低；葡萄糖耐量、肝脏和心血管结构与功能得到改善；血浆三酰甘油和总胆固醇降低。心脏和肝脏中的炎性细胞浸润减少。
CB和PM干预产生了相似的反应，表明花青素是通过预防炎症诱导的损伤来减轻或逆转代谢综合征的生物活性分子。
