Gannan Medical University, Ganzhou, Jiangxi 341000, China.
Xingguo People's Hospital, Xingguo, Jiangxi 342400, China.
Oxid Med Cell Longev. 2019 Jun 26;2019:1759149. doi: 10.1155/2019/1759149. eCollection 2019.
Nrf2 (NF-E2-related factor 2) is a master regulator of cellular oxidative levels against environmental stresses. Nrf2 induces the expression of metabolic detoxification and antioxidant enzymes to eliminate reactive oxygen species (ROS). The gastrointestinal tract is a key source of ROS. Intestinal barrier is critical to maintain the healthy steady state of the human gastrointestinal tract. Nrf2 has been shown to play important roles in maintaining the integrity of intestinal mucosal barrier. Here, we made a systematic review on the roles of Nrf2 in maintaining intestinal barrier, including the following: (1) NRF2 reduced intestinal mucosal injury by suppressing oxidative stress; (2) NRF2 decreased intestinal inflammation by inhibiting the inflammatory pathway; (3) NRF2 affected intestinal tight junction proteins and apoptosis of cells to regulate intestinal permeability; (4) NRF2 affected T cell differentiation and functions; (5) the crossregulation between the KEAP1-NRF2 pathway and autophagy controlled intestinal oxidative stress.
Nrf2（NF-E2 相关因子 2）是细胞对环境应激产生氧化水平的主要调节因子。Nrf2 诱导代谢解毒和抗氧化酶的表达，以消除活性氧（ROS）。胃肠道是 ROS 的主要来源。肠道屏障对于维持人类胃肠道的健康稳态至关重要。Nrf2 已被证明在维持肠黏膜屏障的完整性方面发挥着重要作用。在这里，我们对 Nrf2 在维持肠道屏障中的作用进行了系统综述，包括：（1）NRF2 通过抑制氧化应激来减少肠道黏膜损伤；（2）NRF2 通过抑制炎症途径来减少肠道炎症；（3）NRF2 影响肠道紧密连接蛋白和细胞凋亡来调节肠道通透性；（4）Nrf2 影响 T 细胞分化和功能；（5）KEAP1-NRF2 通路和自噬对肠道氧化应激的交叉调节。
