长链非编码 RNA 的失调表达可作为 2 型糖尿病的诊断生物标志物。
Dysregulated expression of long noncoding RNAs serves as diagnostic biomarkers of type 2 diabetes mellitus.
机构信息
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
出版信息
Endocrine. 2019 Sep;65(3):494-503. doi: 10.1007/s12020-019-02015-7. Epub 2019 Jul 25.
PURPOSE
Long noncoding RNAs (LncRNAs) are widely investigated in various diseases as a novel type of biomarkers. We aimed to elucidate the diagnostic values of lncRNAs in patients with type 2 diabetes mellitus (T2DM).
METHODS
We comprehensively searched PubMed, Web of Science, EMBASE, CBM, Scopus, and the Cochrane Library databases from the inception to 3 January 2019. Studies concerning the association between lncRNAs expression and diagnostic outcomes in type 2 diabetes mellitus patients were included. We employed pooled odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate diagnostic parameters.
RESULTS
Seven relevant studies were eligible in our study. The pooled results showed that lncRNAs performed the area under the curve (AUC) of 0.73 (95%Cl: 0.69-0.77), with sensitivity of 0.71 (95%Cl: 0.64-0.77) and specificity of 0.66 (95%Cl: 0.60-0.71) in discriminating type 2 diabetes from healthy controls. As for prediabetes, lncRNAs conducted AUC of 0.75 with 76% sensitivity and 64% specificity. Moreover, subgroup analysis based on expression levels of lncRNAs, sample sizes, and specimen of eligible studies were further performed.
CONCLUSIONS
This study indicates that lncRNAs may serve as promising indicators for diagnostic evaluation of T2DM patients.
目的
长链非编码 RNA（lncRNAs）作为一种新型生物标志物，在各种疾病中得到了广泛研究。我们旨在阐明 lncRNAs 在 2 型糖尿病（T2DM）患者中的诊断价值。
方法
我们全面检索了 PubMed、Web of Science、EMBASE、CBM、Scopus 和 Cochrane Library 数据库，检索时间截至 2019 年 1 月 3 日。纳入了有关 lncRNAs 表达与 2 型糖尿病患者诊断结果之间关联的研究。我们采用汇总优势比（ORs）和 95%置信区间（CIs）来评估诊断参数。
结果
本研究纳入了 7 项相关研究。汇总结果显示，lncRNAs 的曲线下面积（AUC）为 0.73（95%CI：0.69-0.77），鉴别 2 型糖尿病与健康对照者的敏感度为 0.71（95%CI：0.64-0.77），特异度为 0.66（95%CI：0.60-0.71）。对于糖尿病前期，lncRNAs 的 AUC 为 0.75，敏感度为 76%，特异度为 64%。此外，我们还进一步基于 lncRNAs 的表达水平、样本量和合格研究的标本进行了亚组分析。
结论
本研究表明，lncRNAs 可能是 T2DM 患者诊断评估的有前途的指标。
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