Pressler T, Mansa B, Jensen T, Pedersen S S, Høiby N, Koch C
Department of Paediatrics, Rigshospitalet, Copenhagen, Denmark.
Acta Paediatr Scand. 1988 Jul;77(4):576-82. doi: 10.1111/j.1651-2227.1988.tb10703.x.
The concentrations of IgG subclass immunoglobulins were determined by radial immunodiffusion in serum from 126 patients with cystic fibrosis (CF). The results were compared to values from age-matched healthy children and adults and correlated to patients age, duration of chronic Pseudomonas aeruginosa infection and lung function parameters. Fifty-two percent of the patients had an elevated concentration of at least one of the IgG subclasses; IgG1 28%, IgG2 16%, IgG3 18% and IgG4 48%. There was significant correlation between elevated serum levels of IgG2, and to a lesser extent IgG3, with decreased lung function (for FEV1; p = 0.0001, and p = 0.001 respectively) and high levels of antipseudomonas precipitins (p = 0.008, and p = 0.002). A similar correlation was not found for IgG1 and IgG4. IgG subclasses vary in their ability to promote phagocytosis and to activate complement and it is possible that individual differences in the IgG subclass pattern could explain the variable course of this disease.
采用放射免疫扩散法测定了126例囊性纤维化（CF）患者血清中IgG亚类免疫球蛋白的浓度。将结果与年龄匹配的健康儿童和成人的值进行比较，并与患者的年龄、慢性铜绿假单胞菌感染持续时间和肺功能参数相关联。52%的患者至少有一种IgG亚类浓度升高；IgG1升高的占28%，IgG2升高的占16%，IgG3升高的占18%，IgG4升高的占48%。血清IgG2水平升高与肺功能下降（FEV1；p = 0.0001）以及高水平的抗铜绿假单胞菌沉淀素（p = 0.008）之间存在显著相关性，IgG3水平升高与肺功能下降（p = 0.001）以及高水平的抗铜绿假单胞菌沉淀素（p = 0.002）之间也存在显著相关性，但程度较轻。未发现IgG1和IgG4有类似的相关性。IgG亚类在促进吞噬作用和激活补体的能力方面存在差异，IgG亚类模式的个体差异可能解释了这种疾病的不同病程。
