Xi Zeng, Jing Li, Le-Ni Kang, Zhu Lan, Ze-Wen Deng, Hui Ye, Ming-Rong Xi, Guang-Dong Liao
Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu.
Medicine (Baltimore). 2019 Jul;98(30):e16345. doi: 10.1097/MD.0000000000016345.
To evaluate the potential role of Pten and CD4FOXP3 T cells in prognosis from endometrial cancer.Tissue samples and clinical data were collected from 200 patients with endometrial cancer and 100 control patients with benign uterine diseases. The expressions of Pten and CD4FOXP3 T cells were quantified by immunohistochemistry and immunofluorescence. After surgery, all patients were followed up for an average of 56.3 months. Surgical effects were evaluated based on the patients' symptoms and signs. A two-sided P value < .05 was considered significant.Pten diminished and CD4FOXP3 T cells significantly accumulated with the progression of endometial cancer, in comparison to the controls. Moreover, Pten expression was negatively correlated with the count of CD4FOXP3 T cells. Pten and CD4FOXP3 T cells were correlated with clinical characteristics, including tumor stage, differentiation and associated with patients' disease-free survival.Limited data were available between the expressions of Pten and CD4FOXP3 T cells in patients with endometrial cancer. Our study findings suggested that the expressions of Pten and CD4FOXP3 T cells might become possible biomarkers for the diagnosis and prediction in endometrial cancer.
评估Pten和CD4FOXP3 T细胞在子宫内膜癌预后中的潜在作用。收集了200例子宫内膜癌患者和100例良性子宫疾病对照患者的组织样本及临床数据。通过免疫组织化学和免疫荧光对Pten和CD4FOXP3 T细胞的表达进行定量。术后，所有患者平均随访56.3个月。根据患者的症状和体征评估手术效果。双侧P值<0.05被认为具有统计学意义。与对照组相比，随着子宫内膜癌的进展，Pten表达降低，CD4FOXP3 T细胞显著积聚。此外，Pten表达与CD4FOXP3 T细胞计数呈负相关。Pten和CD4FOXP3 T细胞与临床特征相关，包括肿瘤分期、分化程度，并与患者的无病生存期相关。关于子宫内膜癌患者中Pten和CD4FOXP3 T细胞表达之间的数据有限。我们的研究结果表明，Pten和CD4FOXP3 T细胞的表达可能成为子宫内膜癌诊断和预测的潜在生物标志物。
