Idrissi Moulay, Espitalier Fabien, Coveney Richard, Bélanger Marie-Eve, Gobert Quentin, Sidéris Lucas, Dubé Pierre, Verdonck Olivier, Fortier Louis-Philippe, Richebé Philippe
Maisonneuve-Rosemont Hospital Research Center (CR-HMR).
Department of Anesthesiology and Pain Medicine.
Medicine (Baltimore). 2019 Jul;98(30):e16467. doi: 10.1097/MD.0000000000016467.
The impact of the anesthesia management during cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of colorectal peritoneal carcinomatosis (CRPC) on postoperative outcomes might be of major importance in the process of postoperative recovery. It might have a significant impact on intra- and postoperative outcomes, but the evaluation of this impact seems to be under-reported. To investigate the question whether the anesthesia management was reported in previous studies done in this population and if it had any impact on postoperative outcomes, we propose to conduct a systematic review of the published literature.
For this review, we will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Medline/PubMed, Embase, EBM Reviews and the Cochrane Database of Systematic Reviews (CDSR) will be systematically consulted for eligible studies without age, gender, ethnic, and language restriction. The goal of this review will be to assess whether anesthesia monitoring, dosing, and analgesia protocols were reported in this literature on this specific procedure and whether the impact of the anesthesia management on intraoperative safety and postoperative recovery was evaluated.
The results of this systematic review will allow to answer the initial question: has the impact of anesthesia management on intraoperative safety and patients' postoperative recovery already been studied and reported in the past for this type of major surgery? And does anesthesia have any impact on postoperative outcomes?
In the hypothesis that the impact of anesthesia management on patients' postoperative recovery has never been studied, or very little reported in previous studies in this type of major surgery, it would be justified to conduct a randomized controlled trial on this specific objective.
This systematic review protocol was registered in PROSPERO, under the registration number CRD42019124162.
在减瘤手术（CRS）联合热灌注腹腔化疗（HIPEC）治疗结直肠癌腹膜转移癌（CRPC）过程中，麻醉管理对术后恢复的影响在术后恢复过程中可能至关重要。它可能对术中和术后结果产生重大影响，但对此影响的评估似乎报道不足。为了调查在该人群之前进行的研究中是否报道了麻醉管理以及它是否对术后结果有任何影响，我们建议对已发表的文献进行系统综述。
对于本综述，我们将遵循系统评价与Meta分析方案的首选报告项目（PRISMA - P）。将系统查阅Medline/PubMed、Embase、循证医学综述和Cochrane系统评价数据库（CDSR）以获取符合条件的研究，不受年龄、性别、种族和语言限制。本综述的目的是评估关于该特定手术的文献中是否报道了麻醉监测、给药和镇痛方案，以及是否评估了麻醉管理对术中安全性和术后恢复的影响。
本系统综述的结果将有助于回答最初的问题：过去对于这类大手术，麻醉管理对术中安全性和患者术后恢复的影响是否已经得到研究和报道？麻醉对术后结果有任何影响吗？
假设麻醉管理对患者术后恢复的影响从未被研究过，或者在这类大手术的先前研究中报道很少，那么针对这一特定目标进行一项随机对照试验将是合理的。
本系统综述方案已在PROSPERO注册，注册号为CRD42019124162。
