铜绿假单胞菌外膜蛋白的改变与对喹诺酮类药物的选择性耐药相关。
Alterations in outer membrane proteins of Pseudomonas aeruginosa associated with selective resistance to quinolones.
作者信息
Daikos G L, Lolans V T, Jackson G G
机构信息
Department of Medicine, University of Illinois College of Medicine, Chicago 60680.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):785-7. doi: 10.1128/AAC.32.5.785.
Abstract
Electrophoresis of outer membrane proteins in three ciprofloxacin-resistant strains of Pseudomonas aeruginosa isolated during therapy and their in vitro revertants indicated that diminution or loss of a 31- to 32-kilodalton outer membrane protein correlated with resistance in two of the three isolates. Resistance was unstable and caused no cross-resistance with other antibiotics.
摘要
对治疗期间分离出的三株耐环丙沙星铜绿假单胞菌及其体外回复突变株的外膜蛋白进行电泳分析，结果表明，在这三株分离株中的两株中，一种31至32千道尔顿的外膜蛋白的减少或缺失与耐药性相关。耐药性不稳定，且不会引起对其他抗生素的交叉耐药。
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